297148-39-1Relevant academic research and scientific papers
Antiproliferative potency of novel benzofuran-2-carboxamides on tumour cell lines: Cell death mechanisms and determination of crystal structure
Hranjec, Marijana,Sovic, Irena,Ratkaj, Ivana,Pavlovic, Gordana,Ilic, Natasa,Valjalo, Linda,Pavelic, Kresimir,Kraljevic Pavelic, Sandra,Karminski-Zamola, Grace
, p. 111 - 119 (2013/03/13)
In this manuscript the synthesis and biological activity of novel heterocyclic derivatives of benzofuran-2-carboxamides 3a-j and 6a-f is presented. Biological evaluation in vitro revealed that only few compounds exerted concentration-depended antiproliferative effects on tumour cell lines at micromolar concentrations. In particular, 2-imidazolynyl substituted compound 6f showed selectivity on SK-BR-3 cell line while 2-N-acetamidopyridyl substituted 3h and 2-imidazolynyl substituted amide 3i showed selective concentration-dependent antiproliferative effects on SW620 cell line. Compounds 3h and 6f induced apoptosis while compound 3i acted through a cell death mechanism other than apoptosis.
