297162-36-8

Basic information

• Product Name: 2-amino-4-(2,5-dimethoxyphenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
• Synonyms: 2-amino-4-(2,5-dimethoxyphenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
• CAS NO: 297162-36-8
• Molecular Formula: C₂₀H₂₂N₂O₄
• Molecular Weight: 354.39968
• Mol File: 297162-36-8.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-amino-4-(2,5-dimethoxyphenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-4-(2,5-dimethoxyphenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile(297162-36-8)
• EPA Substance Registry System: 2-amino-4-(2,5-dimethoxyphenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile(297162-36-8)

Safety Data

• Hazardous Substances Data: 297162-36-8(Hazardous Substances Data)

Upstream product

• 126-81-8 dimedone 
• 93-02-7 2,5-dimethoxybenzaldehyde 
• 109-77-3 malononitrile 

Relevant articles and documents

Mechanical ball milling auxiliary synthesis method 2 -amino -3 - cyano - 4H - pyran compound

The invention relates to the technical field of chemical synthesis, and aims to solve the problems that 2 - amino -3 - cyano - 4H - pyran compounds are large in pollution and tedious in preparation in the prior art, and discloses a mechanical ball milling auxiliary synthesis method 2 -amino -3 - cyano - 4H - pyran compound which comprises the following steps: (a) the substrate 1. The substrate 2 and malononitrile were subjected to mechanical ball milling after addition of a protein catalyst and a grinding aid as a raw material. (b) Ball milling, the reactants are scraped off, the solvent is added, and the solvent is added, and after filtration, 2 - amino -3 - cyano - 4H - pyran compounds are prepared by column chromatography. The mechanical ball milling technology facilitates mutual contact of reactant molecules, realizes no solvent reaction, and is easily available to the environment. The method effectively realizes the green synthesis of 2 - amino -3 - cyano - 4H - pyran compounds, and is mild in preparation conditions, simple and convenient to operate and high in reaction rate.

Polyethylene Glycol-(N-Methylimidazolium) Hydroxide-Grafted γ-Fe2O3@HAp: A Novel Nanomagnetic Recyclable Basic Phase-Transfer Catalyst for the Synthesis of Tetrahydrobenzopyran Derivatives in Aqueous Media

Polyethylene glycol-(N-methylimidazolium) hydroxide-grafted hydroxyapatite encapsulated γ-Fe2O3 nanoparticles, γ-Fe2O3@HAp@PEG(mim)OH, were prepared and characterized by FTIR, SEM, TEM, TGA, and EDAX. This nanoc

Facile pathway for synthesis of two efficient catalysts for preparation of 2-aminothiophenes and tetrahydrobenzo[b]pyrans

Abstract: We report here a new magnetically recyclable catalyst consisting of iron-substituted Keggin-type heteropolyacid (HPA) grafted on modified Fe3O4 nanoparticles. The synthesized hybrid nanomaterial exhibited the excellent catalytic efficiency in condensation reaction for the preparation of tetrahydrobenzo[b]pyrans under solvent-free conditions as well as in the synthesis of 2-aminothiophenes via Gewald reaction. It must be noted that, HPA supported magnetite nanoparticles catalyzed the preparation of tetrahydrobenzo[b]pyrans, whereas for Gewald reaction amine-functionalized magnetite nanoparticles acted as a catalyst. Different characterization techniques such as Fourier transform infrared (FT-IR), X-ray powder diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM) were used to characterize the hybrid nanomaterial. The reusability of catalyst was affirmed by using in consecutive runs for five times. Performance of prepared catalyst was compared with the various previously reported catalysts; the newly synthesized catalysts found to be most efficient with regard to reaction time, yield and ease of catalyst separation. Graphical Abstract: [Figure not available: see fulltext.].