297171-80-3

Basic information

• Product Name: 4-(4-Methyl-4H-1,2,4-triazol-3-yl)piperidine hydrochloride
• Synonyms: 4-(4-Methyl-4H-1,2,4-triazol-3-yl)piperidine hydrochloride;Piperidine, 4-(4-Methyl-4H-1,2,4-triazol-3-yl)-, hydrochloride (1:1)
• CAS NO: 297171-80-3
• Molecular Formula: C8H14N4.HCl
• Molecular Weight: 202.69
• EINECS: 604-604-1
• Mol File: 297171-80-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-(4-Methyl-4H-1,2,4-triazol-3-yl)piperidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Methyl-4H-1,2,4-triazol-3-yl)piperidine hydrochloride(297171-80-3)
• EPA Substance Registry System: 4-(4-Methyl-4H-1,2,4-triazol-3-yl)piperidine hydrochloride(297171-80-3)

Safety Data

• Hazardous Substances Data: 297171-80-3(Hazardous Substances Data)

Usage

General Description

"4-(4-Methyl-4H-1,2,4-triazol-3-yl)piperidine hydrochloride" is a complex organic compound with potential applications in chemical research. The presence of a 1,2,4-triazolyl group linked to a piperidine ring suggests its relevance in the synthesis of pharmaceuticals, particularly those involving heterocyclic building blocks. The hydrochloride form signifies it comes as a salt, which generally improves its solubility in polar solvents, enhancing its utility in various lab procedures. Though specific properties such as toxicity or exact uses may vary, such chemical structure suggests a potential role as an intermediate in the synthesis of more complex molecules.

Upstream product

• 187834-88-4 tert-butyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate 

Relevant articles and documents

NOVEL INHIBITORS

The invention relates to a compound of formula (I): A-B-D-E (I) or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, wherein: A is selected from monocyclic and bicyclic heteroaryl, which may independently substituted by alkyl or amino; B is selected from alkyl, heteroalkyl, alkyl-amino, aryl, heteroaryl, cycloalkyl, heterocyclyl and alkylene, wherein said groups may independently be substituted by alkyl; D is selected from aryl-amino, heteroaryl-amino, cycloalkyl-amino, heterocyclyl, heterocyclyl-amino, urea, thioamide, thiourea, sulfonamide, sulfoximine and sulfamoyl, wherein said aryl, heteroaryl, cycloalkyl and heterocyclyl groups may independently be substituted; and E is selected from aryl, heteroaryl, cycloalkyl, heterocyclyl, wherein said aryl, heteroaryl, cycloalkyl and heterocyclyl groups may independently be substituted. The compounds of formula (I) are inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N- terminal glutamate residues into pyroglutamic acid under liberation of water.