2972-71-6

Usage

Uses

Used in Pharmaceutical Industry:
((3-FLUOROPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE is used as a building block for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, ((3-FLUOROPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE is utilized as a key intermediate for the production of agrochemicals, aiding in the creation of effective pest control solutions and other agricultural products.
Used in Dye and Pigment Industry:
((3-FLUOROPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE is employed as a precursor in the manufacturing process of dyes and pigments, enabling the production of a wide array of colorants for various applications.
Used in Material Science:
((3-FLUOROPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE has potential applications in the development of novel materials, where it can be used to create innovative substances with unique properties for diverse industries.
Used in Biological Research:
((3-FLUOROPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE also finds utility in biological research, where it can be employed as a tool to study various biological processes and develop new research methodologies.

Upstream product

• 456-47-3 3-fluoro-benzenemethanol 
• 109-77-3 malononitrile 
• 456-48-4 3-Fluorobenzaldehyde 

Downstream Products

• 136494-57-0 4-Cyclopropyl-6-(3-fluoro-phenyl)-2-imino-cyclohex-3-ene-1,1,3-tricarbonitrile 
• 107752-90-9 2-amino-4-(3-fluorophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile 
• 107752-98-7 2-amino-4-(3-fluorophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile 
• 103868-27-5 4-(3-Fluoro-phenyl)-6-methyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile 
• 94639-07-3 6-Amino-4-(3-fluoro-phenyl)-2,2-dimethyl-4H-[1,3]dithiine-5-carbonitrile 
• 89607-36-3 6-Amino-4-(3-fluoro-phenyl)-3-methyl-1,4-dihydro-pyrano[2,3-c]pyrazole-5-carbonitrile 
• 111861-40-6 2-Amino-3-cyano-7-amino-4-(3-fluorophenyl)-4H-chromene 
• 84186-25-4 2-amino-4-(3-fluorophenyl)-3-cyano-4H-naphtho<2,1-b>pyran 
• 133828-92-9 (2S,3S,8aR)-1,1,6-Tricyano-2-(3-fluoro-phenyl)-1,2,3,8a-tetrahydro-indolizine-3-carboxylic acid amide 
• 111861-34-8 2-Amino-4-(3-fluoro-phenyl)-6-hexyl-7-hydroxy-4H-chromene-3-carbonitrile 
• 94638-85-4 4-(3-Fluoro-phenyl)-5,6-dimethyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile 
• 94833-77-9 2-Amino-4-(3-fluoro-phenyl)-1,5-dithia-spiro[5.5]undec-2-ene-3-carbonitrile 
• 94833-80-4 4-(3-Fluoro-phenyl)-2-thioxo-1,2,5,6,7,8-hexahydro-quinoline-3-carbonitrile 
• 876709-71-6 2-amino-4-(3-fluorophenyl)-6-hydroxymethyl-8-oxo-4H,8H-pyrano[3,2-b]pyran-3-carbonitrile 

Relevant academic research and scientific papers

Kinetically Controllable Pd-Catalyzed Decarboxylation Enabled [5 + 2] and [3 + 2] Cycloaddition toward Carbocycles Featuring Quaternary Carbons

A decarboxylative protocol has been developed toward a range of carbocycles. The key success is based on the use of a batch of newly designed cyclic carbonates as substrates that can provide carbon-carbon zwitterion intermediate under palladium catalysis.

Metal-free multicomponent synthesis of novel macrocyclic tetrathiadienes with cyano and amino groups

The first synthesis of 5,12-diamino-7,14-bis(aryl)-1,4,8,11-tetrathiacyclotetradeca-5,12-diene-6,13-dicarbonitriles was performed as a multicomponent macroheterocyclization of malononitrile, aryl aldehydes, and 1,2-ethanedithiol in the presence of a catal

Discovery of Highly Potent Adenosine A1Receptor Agonists: Targeting Positron Emission Tomography Probes

Adenosine receptor (AR) radiotracers for positron emission tomography (PET) have provided knowledge on the in vivo biodistribution of ARs in the central nervous system (CNS), which is of therapeutic interest for various neuropsychiatric disorders. Additio

Phosphine-Catalyzed (4 + 2) Annulation of δ-Sulfonamido-Substituted Enones with 1,1-Dicyanoalkenes: Synthesis of Piperidine Derivatives

The δ-sulfonamido-substituted enones were employed as phosphine acceptor in phosphine-catalyzed (4 + 2) annulation of 1,1-dicyanoalkenes. They served as a four-membered synthon to react with 1,1-dicyanoalkenes under mild reaction conditions, producing pip

Manganese-organic framework assembled by 5-((4′-(tetrazol-5″-yl)benzyl)oxy)isophthalic acid: A solvent-free catalyst for the formation of carbon–carbon bond

A new three-dimensional manganese-based metal–organic framework Mn4L2(HL)(H2O)5, (1), based on semi-rigid 5-((4′-(tetrazol-5′’-yl)benzyl)oxy)isophthalic acid ligand (H3L) have been prepared and charac

Synthesis, structure, and catalytic properties of a copper(II) coordination polymer material constructed from 5-nitro-1,2,3-benzenetricarboxylic acid and bis(4-pyridylformyl)piperazine mixed ligands

One three-dimensional coordination polymer material, {[Cu3(nbta)2(bpfp)2(H2O)2](H2O)2}n (H3nbta = 5-nitro-1,2,3-benzenetricarboxylic acid, bpfp = bis(4-pyri

Unexpected polymorphism during a catalyzed mechanochemical Knoevenagel condensation

The transformation of a base-catalyzed, mechano-assisted Knoevenagel condensation of mono-fluorinated benzaldehyde derivatives (p-, m-, o-benzaldehyde) with malonodinitrile was investigated in situ and in real time. Upon milling, the para-substituted prod

Construction of two Zn(ii)/Cd(ii) multifunctional coordination polymers with mixed ligands for catalytic and sensing properties

With the purpose of exploring the catalytic and sensing properties of crystalline materials, two coordination polymers were rationally constructed by the reactions of Zn(ii)/Cd(ii) ions with methyl-3-hydroxy-5-carboxy-2-thiophenecarboxylate (H2

Stereoselective one-pot synthesis of polycyanosubstituted piperidines

Abstract: An effective and facile multicomponent method for the synthesis of polysubstituted piperidines is described. The Michael–Mannich type cascade of benzylidenemalononitriles with aromatic aldehydes and ammonium acetate or aqueous ammonia provides c

H3PW12O40/mpg-C3N4 as an efficient and reusable bifunctional catalyst in one-pot oxidation-Knoevenagel condensation tandem reaction

A single-site bifunctional catalyst for the oxidation-Knoevenagel condensation tandem reaction was prepared by the immobilization of phosphotungstic acid (HPW) on mesoporous graphitic carbon nitride (mpg-C3N4) via electrostatic interaction (HPW/mpg-C3N4). The results of Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), solid-state 31P nuclear magnetic resonance (solid-state 31P NMR), zeta potentials, X-ray photoelectron spectroscopy (XPS) and thermogravimetric analysis (TGA) demonstrated that HPW was successfully immobilized on the protonated mpg-C3N4 by electrostatic interaction. The acid amounts of the catalysts were determined by NH3 temperature programmed desorption (NH3-TPD). The textural properties and morphology of HPW/mpg-C3N4 were characterized by N2 adsorption-desorption, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). 30% HPW/mpg-C3N4 shows the best catalytic performance in the tandem reaction with 98.4% benzyl alcohol conversion and 96.2% selectivity to benzylidene malononitrile. The excellent catalytic performance of 30% HPW/mpg-C3N4 in the tandem reaction is due to the good catalytic performance of HPW in the oxidation and Knoevenagel condensation, respectively. Furthermore, protonated mpg-C3N4 not only acts as a support to facilitate good dispersion of HPW but also promotes the Knoevenagel condensation reaction effectively. Moreover, the HPW/mpg-C3N4 catalyst could be recycled easily without significant loss of catalytic activity.