2972-72-7Relevant articles and documents
A multifunctional triazine-based nanoporous polymer as a versatile organocatalyst for CO2 utilization and C-C bond formation
Sharma, Ruchi,Bansal, Ankushi,Ramachandran,Mohanty, Paritosh
, p. 11607 - 11610 (2019)
A triazine-based nanoporous multifunctional polymer with a SABET of 304 m2 g-1 has shown versatile catalytic activity in the conversion of CO2 to cyclic carbonates at 4 bar with almost 100% yield and selectivity, and in the conversion of CO2 to methanol and methane electrochemically. Additionally, it also catalyzes C-C bond formation via the Knoevenagel reaction.
Coordination driven self-assembly of [2 + 2 + 2] molecular squares: Synthesis, crystal structures, catalytic and luminescence properties
Gupta, Vijay,Mandal, Sanjay K.
, p. 9742 - 9754 (2018)
The one-pot self-assembly of three components (metal acetates as the metal precursor, the tridentate polypyridyl ligand, N,N′-bis(2-pyridylmethyl)-tert-butylamine (bpta), as a capping ligand and bent dicarboxylic acids, 4,4′-(dimethylsilanediyl)bis-benzoi
Synthesis, molecular docking studies, and biological evaluation of novel alkyl bis(4-amino-5-cyanopyrimidine) derivatives
Boualia, Imen,Derabli, Chamseddine,Boulcina, Raouf,Bensouici, Chawki,Yildirim, Muhammet,Birinci Yildirim, Arzu,Mokrani, El Hassen,Debache, Abdelmadjid
, (2019)
A series of bis(4-amino-5-cyano-pyrimidines) was synthesized and evaluated as dual inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). To further explore the multifunctional properties of the new derivatives, their antioxidant and antibacterial activities were also tested. The results showed that most of these compounds could effectively inhibit AChE and BChE. Particularly, compound 7c exhibited the best AChE inhibitory activity (IC50 = 5.72 ± 1.53 μM), whereas compound 7h was identified as the most potent BChE inhibitor (IC50 = 12.19 ± 0.57 μM). Molecular modeling study revealed that compounds 7c, 7f, and 7b showed a higher inhibitory activity than that of galantamine against both AChE and BChE. Anticholinesterase activity of compounds 7h, 7b, and 7c was significant in vitro and in silico for both enzymes, since these compounds have hydrophobic rings (Br-phenyl, dimethyl, and methoxyphenyl), which bind very well in both sites. In addition to cholinesterase inhibitory activities, these compounds showed different levels of antioxidant activities. Indeed, in the superoxide–dimethyl sulfoxide alkaline assay, compound 7j showed very high inhibition (IC50 = 0.37 ± 0.28 μM). Also, compound 7l exhibited strong and good antibacterial activity against Staphylococcus epidermidis and Staphylococcus aureus, respectively. Taking into account the results of biological evaluation, further modifications will be designed to increase potency on different targets. In this study, the obtained results can be a new starting point for further development of multifunctional agents for the treatment of Alzheimer's disease.
Successive oxidation-condensation reactions using a multifunctional gold-supported nanocomposite (Au/MgCe-HDO)
Chandra, Ramesh,Kumar, Loveneesh,Kumar, Rupesh,Sehrawat, Hitesh,Tomar, Ravi,Verma, Nishant
, p. 3472 - 3481 (2022/02/21)
The application of gold-supported nanocomposites is useful in clinical diagnostics because of their ability to provide bio-compatible and sensitive detection systems. A gold-supported magnesium hydroxide and cerium oxide nanocomposite framework (Au/MgCe-HDO) was synthesized and characterized via XRD, XPS, SEM, DLS, TEM, and TGA techniques. The nanocomposite was used as a selective catalyst for the aerobic oxidation of alcohols under mild reaction conditions followed by successive condensation reactions, like Knoevenagel and Claisen-Schmidt condensation. Substituted benzyl alcohols were converted into the corresponding carbonyl compounds in the presence of the Au/MgCe-HDO nanocomposite with O2 gas and toluene as a solvent. We observed that, upon the addition of malononitrile/ethyl cyanoacetate/acetophenone to the catalyst in the aerobic oxidation reaction, the reaction proceeds to produce the corresponding desired condensation product with up to 95% yield.
Synthesis, molecular docking, and in silico ADME prediction of some fused pyrazolo[1,5-a]pyrimidine and pyrazole derivatives as potential antimicrobial agents
Hassan, Ashraf S.,Morsy, Nesrin M.,Awad, Hassan M.,Ragab, Ahmed
, p. 521 - 545 (2021/07/06)
Twenty compounds of pyrazolo[1,5-a]pyrimidines 14a–j and pyrazole derivatives as Schiff bases 16a–j have been synthesized by the reaction of 5-amino-pyrazole derivatives 9a, b with 2-(arylidene)malononitriles 10a–e or various aldehydes 15a–e, respectively
Design and Development of Amine Functionalized Mesoporous Cubic Silica Particles: A Recyclable Catalyst for Knoevenagel Condensation
Gupta, Padmini,Kumar, Lalita S.,Kumar, Yogesh,Shabir, Javaid
, (2021/07/28)
Abstract: The amine functionalized cubic mesoporous silica nanoparticles (cSiO2-NH2) were successfully synthesized through biphasic stratification approach. The synthesized material was characterised by various spectroscopic and phys
Introduction of succinimide as a green and sustainable organo-catalyst for the synthesis of arylidene malononitrile and tetrahydrobenzo[b] pyran derivatives
Hassanzadeh, Fariba,Shirini, Farhad,Mamaghani, Manouchehr,Daneshvar, Nader
, p. 155 - 163 (2021/03/23)
Aim and Objective: In this work, we tried to introduce a non-toxic and stable organic compound named succinimide as a green and efficient organo-catalyst for the promotion of the synthesis of arylidene malononitrile and tetrahydrobenzo[b]pyran derivatives
Application of structurally enhanced magnetite cored polyamidoamine dendrimer for knoevenagel condensation
Hajizadeh, Fatemeh,Maleki, Behrooz,Zonoz, Farrokhzad Mohammadi,Amiri, Amirhassan
, p. 793 - 804 (2020/10/02)
In this paper, the synthesis of magnetic cored amino group terminated dendrimer (Fe3O4@SiO2@PAMAM-G2) through covalent bonding was described. This catalyst was characterized by FT-IR, XRD, FE-SEM, TEM, and TGA d
Development of an efficient, one-pot, multicomponent protocol for synthesis of 8-hydroxy-4-phenyl-1,2-dihydroquinoline derivatives
Tabassum, Rukhsana,Ashfaq, Muhammad,Oku, Hiroyuki
, p. 534 - 547 (2020/12/04)
A one-pot quick and efficient multicomponent reaction has been developed for the synthesis of a new series of functionalized 8-hydroxy-4-phenyl-1,2-dihydroquinoline derivatives using 30 mol% ammonium acetate in ethanol as solvent. This economical protocol
Nickel?alkyne?functionalized metal?organic frameworks: An efficient and reusable catalyst
Chen, Huixin,Cheng, Hua,Li, Jilin,Li, Wei,Liao, Shengyun,Liu, Xin,Ning, Liangmin,Shao, Liming,Tang, Siyuan
, (2021/06/15)
Electron-donating groups in the robust MOF motif are able to provide an excellent catalytic platform, therefore obtaining site-isolated metal sites. In this study, the terminal alkyne is firstly introduced into UiO-66-type metal-organic frameworks (UiO-66-alkyne). Herein, to further study the application potential of this material, a covalently bonded nickel catalyst based on the alkynyl-tagged UiO-66-alkyne has been prepared and afforded us unprecedented highly dispersed and highly efficient catalytic active species. Meanwhile, this nickel-contained catalyst method for joining metals provided an alternative pathway regarding catalyst designing. With UiO-66-alkyne-Ni, the heterogeneous transformation of homogeneous catalysts is realized. Using benzaldehyde and malononitrile as starting materials, we were able to catalyze the Knoevenagel condensation within 45 min under room temperature with yield (> 99 %). Moreover, the recovery rate of the UiO-66-alkyne-Ni also outperformed previous MOFs in both small-scale and gram-level reactions, which shows UiO-66-alkyne-Ni is a potential contributor to the subsequent industrialization.
