2972-75-0

Upstream product

• 93-02-7 2,5-dimethoxybenzaldehyde 
• 109-77-3 malononitrile 
• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 

Downstream Products

• 134305-39-8 3-amino-4-cyano-5-(2,5-dimethoxyphenyl)benzocoumarin 
• 132814-01-8 2-amino-3-cyano-4,7-dihydro-4-(2,5-dimethoxyphenyl)-5-methylpyrano<2,3-c>pyrazole 
• 130715-45-6 3-amino-1-(2,5-dimethoxyphenyl)-1H-benzo[f]chromene-2-carbonitrile 
• 316360-38-0 6-amino-3-propyl-4-(thiophen-2-yl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 
• 296263-62-2 C₁₅H₁₃N₅O₃ 
• 132814-01-8 6-amino-4-(2,5-dimethoxyphenyl)-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 
• 93-02-7 2,5-dimethoxybenzaldehyde 

Relevant academic research and scientific papers

Synthesis, molecular docking, and in silico ADME prediction of some fused pyrazolo[1,5-a]pyrimidine and pyrazole derivatives as potential antimicrobial agents

Twenty compounds of pyrazolo[1,5-a]pyrimidines 14a–j and pyrazole derivatives as Schiff bases 16a–j have been synthesized by the reaction of 5-amino-pyrazole derivatives 9a, b with 2-(arylidene)malononitriles 10a–e or various aldehydes 15a–e, respectively

A Zn based metal organic framework as a heterogeneous catalyst for C-C bond formation reactions

Herein, we report the synthesis and application of a Zn-Bp-BTC MOF (Bp-4,4′-bipyridine; BTC-1,3,5-benzene tricarboxylic acid; MOF-metal organic framework) as a heterogeneous catalyst for mediating organic reactions. Initially, conditions were optimized for the Knoevenagel condensation reaction using Zn-Bp-BTC as a heterogeneous catalyst by varying the solvent, temperature and catalyst loading. Although the reaction proceeded at room temperature using methanol as the solvent, 60 °C offered the best yield in a shorter duration. Under optimized reaction conditions, a wide range of α,β-unsaturated dicyano compounds were prepared from the corresponding carbonyl precursor and malononitrile, the active methylene counterpart. Systematic investigation was also carried out to assess the role of the ligand and metal salt in the Knoevenagel condensation reaction. It was found that the Zn-Bp-BTC MOF catalyzed the reaction efficiently in comparison to its analogue Zn-BTC MOF and precursor Zn(NO3)2·6H2O. Finally, catalytic recycling and stability studies showed that the catalyst is able to mediate the reaction for up to five consecutive cycles without undergoing any significant chemical or morphological changes. Further, the catalyst was tested for its efficacy in a multi-component reaction (MCR). A MCR with the Zn-Bp-BTC MOF as the catalyst afforded good yields and there was no reaction in the absence of the catalyst. Similarly, the catalyst was tested for its efficiency in benzimidazole synthesis.

New quinoline- and isoquinoline-based multicomponent methods for the synthesis of 1,1(3,3)-dicyanotetrahydrobenzoindolizines

Convenient multicomponent methods for the synthesis of benzannulated dihydroindolizines based on quinoline or isoquinoline, malononitrile, aromatic aldehydes and α-halomethylcarbonyl compounds were developed. Several alternative protocols of using the reactants were studied, starting with separate generation of two most probable intermediates and ending with the four-component condensation of all reactants. The scope of applicability of these methods was found, depending on the initial compounds used. The reaction is highly stereoselective with predominant formation of one of the possible isomers.

Calcium ferrite, an efficient catalyst for knoevenagel condensation(A green approach)

Calcium ferrite NPs catalyst have been used as a cheaper and highly efficient catalyst for Knoevenagel condensation of active methylene substrate with various carbonyl compounds affording condensed products in excellent yields in shorter reaction time. Th

Synthesis of Novel 4 H-Chromenes Containing a Pyrimidine-2-Thione Function in the Presence of Fe3O4 Magnetic Nanoparticles and Study of Their Antioxidant Activity

The aim of the present work was to search for identification of novel reactive oxygen species (ROS) scavengers by testing new fused chromenopyrimidinethiones, which was synthesized using Fe3O4 nanoparticles. The new compounds were also tested for their cytotoxic activity. The obtained results showed that the incorporated pyrimidinethione moiety significantly increase antioxidant activity. In conclusion, the study of the pharmacological properties of the new chromenopyrimidinethiones allowed establishing new structure-activity relationships for splitting antioxidant and cytotoxic activity of these compounds.

Polystyrene-immobilized DABCO as a highly efficient and recyclable organocatalyst for the Knoevenagel condensation reaction

Polystyrene-immobilized DABCO was used for the first time as a basic organocatalyst for carbon-carbon bond formation reactions. The supported catalyst could be used as a reusable catalyst in the Knoevenagel condensation of a wide range of aromatic/heterocyclic/α,β-unsaturated aldehydes and ketones with active methylene compounds. The reaction conditions are mild and the method is operationally simple. The reactions proceed in a short time period and with 100% selectivity. The catalyst could be easily separated from the reaction by filtration and recycled ten times without activity loss. Based on the catalyst, a continuous flow process was also developed.

Synthesis of substituted 6-amino-4-aryl-5-cyano-2h,4h-pyrano[2,3-c]pyrazoles. Crystal and molecular structure of 6-amino-5-cyano-3-methyl-4-(2′,4′,6′-triethylphenyl)-2h,4h -pyrano[2,3-c]pyrazole

Substituted 6-aminopyrano[2,3-c]pyazoles were synthesized by the two-component condensation of arylidenemalononitriles and substituted 5-pyazolones or three-component condensation of aromatic aldehydes, malononitrile, and substituted 5-pyazolones. It was

Light Absorption and Emission Properties of Cyanovinyl-substituted Dimethoxybenzenes

Synthetic routes to a range of dyes based on cyanovinyl-substituted dimethoxybenzenes are described.The light absorption and fluorescence properties of these compounds in fluid solution at room temperature are discussed.