2972-77-2 Usage
Description
(5-bromo-2-methoxybenzylidene)propanedinitrile, with the molecular formula C11H8BrNO2, is a yellow solid chemical compound that plays a significant role in organic synthesis and pharmaceutical research. It is recognized for its potential in the development of new drugs and serves as a crucial building block in various chemical reactions.
Uses
Used in Pharmaceutical Research:
(5-bromo-2-methoxybenzylidene)propanedinitrile is used as a key intermediate in the synthesis of pharmaceutical compounds due to its unique structure and reactivity. Its ability to participate in different chemical reactions makes it a valuable asset in the development of novel drugs.
Used in Organic Synthesis:
In the field of organic synthesis, (5-bromo-2-methoxybenzylidene)propanedinitrile is utilized as a reagent for the preparation of various organic compounds. Its versatility in forming different chemical bonds and its stability contribute to its widespread use in this industry.
Used in Antitumor Applications:
(5-bromo-2-methoxybenzylidene)propanedinitrile has shown potential in antitumor activities, making it a promising candidate for further research and development in the field of oncology. Its ability to target and inhibit specific cancer cell processes could lead to the creation of more effective cancer treatments.
Used in Antibacterial Applications:
(5-bromo-2-methoxybenzylidene)propanedinitrile has also demonstrated potential in antibacterial activities, indicating its use in the development of new antibiotics or as a component in existing ones. Its ability to combat bacterial infections could be beneficial in addressing the growing issue of antibiotic resistance.
Used in Material Science:
(5-bromo-2-methoxybenzylidene)propanedinitrile has been studied for its potential use in material science, particularly in the development of new materials with specific properties. Its unique chemical structure and reactivity make it a candidate for creating materials with tailored characteristics for various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 2972-77-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,9,7 and 2 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 2972-77:
(6*2)+(5*9)+(4*7)+(3*2)+(2*7)+(1*7)=112
112 % 10 = 2
So 2972-77-2 is a valid CAS Registry Number.
2972-77-2Relevant articles and documents
Synthesis, antiproliferative and pro-apoptotic effects of nitrostyrenes and related compounds in Burkitt’s lymphoma
Byrne, Andrew J.,Bright, Sandra A.,Fayne, Darren,McKeown, James P.,McCabe, Thomas,Twamley, Brendan,Williams, Clive,Meegan, Mary J.
, p. 181 - 199 (2018/03/13)
Background: Cancers of the lymphatic cells (lymphomas) account for approximately 12% of malignant diseases worldwide. The nitrostyrene scaffold is identified as a lead target structure for the development of particularly effective compounds targeting Burkitt’s lymphoma (BL). Objectives: The aims of the curent study were to synthesise a panel of nitrostyrene compounds and to evaluate their activity in Burkitt’s lymphoma (BL). Methods: A panel of structurally varied compounds were designed and synthesised using Henry Knoevenagel condensation reactions. Single crystal X-Ray analysis confirmed the E configuration for six examples of these novel structures. A number of nitrostyrene-related compounds were also investigated including 1,3-bis(aryl)-2-nitropropenes together with heterocyclic scaffolds containing the nitrovinyl pharmacophore such as 3-nitro-2-phenyl-2H-chromenes. The antiproliferative activities of the compounds were evaluated using the BL cell lines EBV- MUTU-1 and EBV+ DG-75 (chemoresistant) to establish preliminary structure-activity relationships. Results: Lead compounds with optimized nitrostyrene scaffolds and 3-nitro-2-phenyl-2Hchromene structures were successfully established with typical IC50 values of 0.45 μM and 0.47 μM in MUTU-1 cells and 1.41 μM and 1.92 μM, respectively, in DG-75 cells. The mechanism of cell death was identified as apoptotic and the lead compound was found to elicit comparable apoptotic effects to Taxol in Burkitt’s lymphoma cell lines MUTU-1 and DG-75. Conclusion: This class of pharmaceutically active compounds with potential for the treatment of Burkitt’s lymphoma suggest a potential role for nitrostyrene based agents in chemotherapy.
