2972-80-7

Basic information

• Product Name: ((3,4-DIMETHOXYPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE
• Synonyms: RARECHEM AL BX 0062;((3,4-DIMETHOXYPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE;2-(3,4-DIMETHOXYBENZYLIDENE)-MALONONITRILE;AKOS USSH-4110228;(3,4-Dimethoxybenzylidene)malononitrile
• CAS NO: 2972-80-7
• Molecular Formula: C₁₂H₁₀N₂O₂
• Molecular Weight: 214.22
• Mol File: 2972-80-7.mol
• Article Data: 61

Chemical Properties

• Melting Point: 147 °C(Solv: ethanol (64-17-5))
• Boiling Point: 377.3°C at 760 mmHg
• Flash Point: 155.9°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 6.82E-06mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: ((3,4-DIMETHOXYPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: ((3,4-DIMETHOXYPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE(2972-80-7)
• EPA Substance Registry System: ((3,4-DIMETHOXYPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE(2972-80-7)

Safety Data

• Hazardous Substances Data: 2972-80-7(Hazardous Substances Data)

Usage

General Description

((3,4-Dimethoxyphenyl)methylene)methane-1,1-dicarbonitrile is a chemical compound with the molecular formula C13H10N2O2. It is a dicarbonitrile derivative of benzaldehyde and is commonly used as a reactant in organic synthesis. The compound is a yellow solid that is sparingly soluble in water but soluble in organic solvents. It is primarily used in the production of pharmaceuticals, agrochemicals, and other specialty chemicals. The compound has potential applications in drug discovery and development due to its unique chemical structure and reactivity. Additionally, it is used as a building block for the synthesis of various organic compounds.

InChI:InChI=1/C12H10N2O2/c1-15-11-4-3-9(6-12(11)16-2)5-10(7-13)8-14/h3-6H,1-2H3

Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 109-77-3 malononitrile 
• 4230-93-7 3,4-dimethoxynitrostyrene 
• 110-89-4 piperidine 
• 326886-35-5 C₁₇H₁₇NO₃ 
• 59276-33-4 veratraldehyde dimethyl acetal 
• 93-03-8 (3,4-dimethoxyphenyl)methanol 
• 27895-67-6 N-(3,4-dimethoxybenzylidene)aniline 

Downstream Products

• 137444-74-7 4-(3,4-dimethoxyphenyl)-2-methoxy-6-(2-thienyl)nicotinonitrile 
• 137444-64-5 2-cyano-3-(3,4-dimethoxyphenyl)-5-oxo-5-(2-thienyl)valeronitrile 
• 153334-59-9 2-amino-3-cyano-4H-4-(3,4-dimethoxyphenyl)-5-methyl-7-phenyl-pyrano<2,3-c>-pyrazole 
• 130715-44-5 3-amino-1-(3,4-dimethoxyphenyl)-1H-benzo[f]chromene-2-carbonitrile 
• 127118-64-3 2,6-diamino-4-(3,4-dimethoxyphenyl)-4H-thiopyran-3,5-dicarbonitrile 
• 487061-96-1 7-amino-6-cyano-5-(3,4-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione 
• 164410-72-4 2?amino?3?cyano?7,7?dimethyl?4?(3,4?dimethoxyphenyl)?5?oxo?4H?5,6,7,8?tetrahydro benzopyran 
• 312276-02-1 6-amino-5-cyano-4-(3,4-dimethoxyphenyl)-2-methyl-4H-pyran-3-carboxylic acid ethyl ester 
• 791619-83-5 2-amino-4-(3,4-dimethoxyphenyl)-6-(phenylsulfanyl)-3,5-pyridinedicarbonitrile 
• 1044264-76-7 2-[1-(3,4-dimethoxyphenyl)-2,2,2-trifluoroethyl]malononitrile 
• 680215-01-4 1,6-diamino-4-(3,4-dimethoxyphenyl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile 
• 1042965-89-8 2-amino-4-(3,4-dimethoxy-phenyl)-6-furan-2-yl-nicotinonitrile 

Relevant articles and documents

A new imidazole-functionalized 3D-cobalt metal-organic framework as a high efficiency heterogeneous catalyst for Knoevenagel condensation reaction of furfural

We have synthesized a new 3D Co(Ⅱ) based metal-organic framework [Co(pytpy)(AIP)·H2O]n(1)(C2/c)(pytpy = 4’-(4-pyridyl)-4,2’:6′,4″-terpyridine,AIP = 5-aminoisophthalic acid) by solvothermal method. Its crystal structure was determined

A mononuclear Cu(II)-based metal-organic framework as an efficient heterogeneous catalyst for chemical transformation of CO2 and Knoevenagel condensation reaction

A novel 2D Cu(II) metal-organic framework, [(Cu(L)2·(H2O)2·(NO3)2]n (namely 1), can be synthesized by the self-assemble of 4-(5-methyl-3-pyridine)-1,2,4-triazole (namely L) and Cu(II) ion.

Two 3D Metal-Organic Frameworks Based on CoII and ZnII Clusters for Knoevenagel Condensation Reaction and Highly Selective Luminescence Sensing

Two metal-organic frameworks (MOFs) with 3D structures, {[Co24(BDPO)12(H2O)12]·18DMF·40H2O}n (1) and {[NH2(CH3)2]4[Zn3(HBDPO)2/s

Two PbII-based coordination polymers based on 5-aminonicotinic acid and 5-hydroxynicotinic acid for Knoevenagel condensation reaction and luminescent sensor

Two new PbII-based coordination polymers based on 5-aminonicotinic acid (namely HL–NH2) and 5-hydroxynicotinic acid (namely HL–OH) are both successfully synthesized under solvothermal synthesis conditions. PbCl2 and HL-NH

Kinetically Controllable Pd-Catalyzed Decarboxylation Enabled [5 + 2] and [3 + 2] Cycloaddition toward Carbocycles Featuring Quaternary Carbons

A decarboxylative protocol has been developed toward a range of carbocycles. The key success is based on the use of a batch of newly designed cyclic carbonates as substrates that can provide carbon-carbon zwitterion intermediate under palladium catalysis.

Metal-free multicomponent synthesis of novel macrocyclic tetrathiadienes with cyano and amino groups

The first synthesis of 5,12-diamino-7,14-bis(aryl)-1,4,8,11-tetrathiacyclotetradeca-5,12-diene-6,13-dicarbonitriles was performed as a multicomponent macroheterocyclization of malononitrile, aryl aldehydes, and 1,2-ethanedithiol in the presence of a catal