29727-88-6

Upstream product

• 4090-55-5 2-chloro-5,5-dimethyl[1,3,2]dioxaphosphinane 2-oxide 

Downstream Products

• 37390-52-6 (5,5-Dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-(2,2-diphenyl-vinyl)-amine 
• 37390-54-8 (E)-3-(5,5-Dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-ylamino)-2-phenyl-acrylic acid methyl ester 
• 1095992-01-0 N-(5,5-dimethyl-1,3,2-dioxaphosphorinan-2-oxo-2-yl)benzaldimine 
• 37390-53-7 (E)-3-(5,5-Dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-ylamino)-2-phenyl-acrylonitrile 

Relevant academic research and scientific papers

Stereoselective synthesis of nipecotic acid derivatives via palladium-catalyzed decarboxylative cyclization of γ-methylidene-δ- valerolactones with imines

(Chemical Equation Presented) A new synthetic method of multisubstituted nipecotic acid (piperidine-3-carboxylic acid) derivatives has been developed by way of palladium-catalyzed decarboxylative cyclization of γ-methylidene- δ-valerolactones with (mines.

Reactivity and diastereoselectivity in the thermal and Lewis acid- catalyzed Diels-Alder reactions of N-sulfinylphosphoramidates

The [4 + 2] cycloaddition reactions of N-sulfinylphosphoromidates, prepared from the corresponding phosphoramidates by treatment with N- (chlorosulfinyl)imidazole, and 1,3-cyclohexadiene were found to be diastereoselective in the absence (>90:10) and presence (> 95:5) of Lewis acid. The sulfur configuration of the major adduct from the cycloaddition reaction has been established unambiguously by X-ray crystallography. The use of Lewis acids improved the diastereoselectivity and yield, as Well as shortened reaction times. Based on the intermediacy of a tin chelate, and the absence of phosphoryl secondary orbital interactions, a mechanism for the cycloaddition reactions is discussed.