29753-99-9

Usage

Uses

Used in Pharmaceutical Synthesis:
Ethyl 3-amino-2-phenylpropanoate hydrochloride is used as a precursor in the pharmaceutical industry for the synthesis of various drugs and medicinal compounds. Its unique structure allows it to be a key intermediate in the production of a range of therapeutic agents.
Used in Organic Compounds Synthesis:
In the field of organic chemistry, ethyl 3-amino-2-phenylpropanoate hydrochloride serves as a valuable starting material for the creation of diverse organic compounds. Its reactivity and functional groups make it suitable for a wide array of chemical reactions, contributing to the development of new chemical entities.
Used in Research and Development:
Ethyl 3-amino-2-phenylpropanoate hydrochloride is utilized in research settings to explore its chemical properties and potential applications. It aids scientists in understanding reaction mechanisms and in the discovery of new synthetic pathways, thus advancing the chemical and pharmaceutical sciences.
Used in Chemical Industry:
Ethyl 3-amino-2-phenylpropanoate hydrochloride finds applications in the chemical industry, where it may be employed in the production of specialty chemicals, fine chemicals, or as a component in various chemical formulations. Its stability and solubility properties make it an advantageous component in industrial processes.

InChI:InChI=1/C11H15NO2.ClH/c1-2-14-11(13)10(8-12)9-6-4-3-5-7-9;/h3-7,10H,2,8,12H2,1H3;1H

Upstream product

• 4553-07-5 ethyl phenylcyanoacetate 
• 952514-97-5 (ethoxycarbonyl)(cyano)(phenyl)methyl dimethyl phosphate 
• 64-17-5 ethanol 

Downstream Products

• 191275-11-3 (R)-benzeneacetic acid α-<<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>methyl>ethyl ester 
• 84936-30-1 ethyl β-(acetylamino)-α-phenylpropionate 
• 191169-84-3 (R)-α-<<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>methyl>benzeneacetic acid 
• 76696-99-6 diphenyl-3,7 oxo-4 hexahydro-2,3,4,6,7,8 pyrrolo<1,2-a>pyrimidine 

Relevant academic research and scientific papers

Cyanide ion promoted addition of acyl phosphonates to ethyl cyanoformate: Synthesis of tertiary carbinols via tandem carbon-carbon bond formations

(Chemical Equation Presented) New cyanation/phosphonate-phosphate rearrangement/C-acylation reactions of cyanophosphate anion with cyanoformate esters are described. Phase-transfer cocatalysts facilitate cyanide-catalyzed reactions between acyl phosphonates and cyanoformates to afford protected tertiary carbinol products in good to excellent yields (74-95%). Ethyl cyanoformate is used as a cyanide source and electrophile. The scope of the reaction was investigated by using a number of benzoyl and acyl phosphonates along with ethyl cyanoformate. Representative chemoselective reduction of the product 5a afforded ethyl 3-amino-2-hydroxy-2-phenylpropanoate (13) in good yield.

PYRIDYLPYRROLE DERIVATIVES ACTIVE AS KINASE INHIBITORS

Pyridylpyrrole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treat

PYRIMIDYLPYRROLE DERIVATIVES ACTIVE AS KINASE INHIBITORS

Pyrimidylpyrrole derivatives of formula (1) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be

Rationally designed 'dipeptoid' analogues of cholecystokinin (CCK): C-terminal structure-activity relationships of α-methyl tryptophan derivatives

This paper outlines the synthesis and C-terminal structure-activity relationships (SAR) of a series of α-methyl tryptophanylphenethylamide analogues of the neuropeptide cholecystokinin (CCK).CCK-B and CCK-A receptor binding affinities of these analogues are described and the contributions of the various side chains on the phenethylamide moiety to binding affinity are discussed.Several of the compounds prepared have CCK-B receptor binding affinities similar to that found with the endogenous neuropeptide CCK-26-33 (sulphated) (CCK-B, IC50 = 0.3 nM) and are highly selective over the CCK-A receptor.Amongst the most potent of the compounds synthesized are *,S*)>-β-3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>benzenebutanoic acid 22, *,S*)>-3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-3-phenylpropyl>thio>acetic acid 28a and *,S*)>-3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-3-phenylpropyl>sulfonyl>acetic acid 32 which have CCK-B receptor binding affinities of IC50 = 0.3, 0.3 and 0.2 nM with CCK-A/B ratios of 220, 700 and 1000, respectively.CCK-B receptor selective ligands, 22, 28a and 32 were also shown to be potent anatagonists in blocking pentagastrin-evoked excitation in neurons of the rat hypothalamic ventro-medial nucleus (VMN) with the Ke values of 2.8, 23 and 5.9 nM, respectively. Keywords: cholecystokinin / dipeptoid analogues / structure-affinity relationships / α-methyl-tryptophan derivatives / C-terminal