2976-02-5

Basic information

• Product Name: 1-(5-bromofuran-2-yl)-3-phenylprop-2-yn-1-one
• Synonyms: 1-(5-bromofuran-2-yl)-3-phenylprop-2-yn-1-one
• CAS NO: 2976-02-5
• Molecular Weight: 275.101
• Mol File: 2976-02-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(5-bromofuran-2-yl)-3-phenylprop-2-yn-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-bromofuran-2-yl)-3-phenylprop-2-yn-1-one(2976-02-5)
• EPA Substance Registry System: 1-(5-bromofuran-2-yl)-3-phenylprop-2-yn-1-one(2976-02-5)

Safety Data

• Hazardous Substances Data: 2976-02-5(Hazardous Substances Data)

Upstream product

• 1899-24-7 5-bromo-2-furancarboxaldehyde 
• 536-74-3 phenylacetylene 
• 26726-16-9 5-bromofuran-2-carbonyl chloride 

Downstream Products

• 2976-09-2 3-(5-bromo-furan-2-yl)-5-phenyl-isoxazole 
• 2976-07-0 3-(5-bromo-furan-2-yl)-5-phenyl-1⁽²⁾H-pyrazole 

Relevant articles and documents

Stitching Ynones with Nitromethanes: Domino Synthesis of Functionally Enriched Benzofurans and Benzothiophenes

A convenient one-pot benzannulation of regioisomeric 2- or 3-substituted furan and thiophene ynones with a range of nitromethanes has been discovered to directly access densely and diversely functionalized benzofurans and benzothiophenes. In this protocol, the nitro group in nitromethanes functions as recursive carbanion activator to setup tandem Michael addition-6π-electrocyclization, and its eventual sacrificial elimination facilitates aromatization and overall benzannulation. This benzannulation was also explored with furan/thiophene based o-halo ynones wherein a Michael addition-SNAr process operates and nitromethanes leave their imprint to deliver nitro substituted benzo-furans and -thiophenes.