2976-08-1

Upstream product

• 5910-23-6 1-furan-2-yl-3-phenyl-propane-1,3-dione 
• 2975-99-7 2-furyl phenylethynyl ketone 
• 717-21-5 3-(furan-1-yl)-1-phenyl-prop-2-en-1-one 
• 53945-98-5 N-hydroxyfuran-2-carbimidoyl chloride 
• 536-74-3 phenylacetylene 

Downstream Products

• 14441-90-8 5-phenyl-3-isoxazolecarboxylic acid 
• 2976-09-2 3-(5-bromo-furan-2-yl)-5-phenyl-isoxazole 

Relevant academic research and scientific papers

Copper(0) Nanoparticles in Click Chemistry: Synthesis of 3,5-Disubstituted Isoxazoles

An efficient procedure for the synthesis of 3,5-disubstituted isoxazoles via [3+2] cycloaddition reaction of in situ generated nitrile oxides with acetylenes employing readily preparable copper(0) nanoparticles is described. A variety of in situ generated

Efficient and regioselective one-pot synthesis of 3-substituted and 3,5-disubstituted isoxazoles

(Figure Presented) A series of 3-substituted and 3,5-disubstituted isoxazoles have been efficiently synthesized in moderate to excellent yields by the reaction of N-hydroxyl-4-toluenesulfonamide with α,β-unsaturated aldehydes/ketones. This novel strategy is associated with readily available starting materials, mild conditions, high regioselectivity, and wide scope.