29767-96-2Relevant academic research and scientific papers
Fused Selenazolinium Salt Derivatives with a Se-N+ Bond: Preparation and Properties
Arsenyan, Pavel,Vasiljeva, Jelena,Belyakov, Sergey,Liepinsh, Edvards,Petrova, Marina
, p. 5842 - 5855 (2015)
Convenient methods for the preparation of stable, fused selenazolinium salt systems with a Se-N+ bond have been developed. The mechanism for the formation of the selenazole cycle was investigated in detail by conducting multinuclear NMR experiments. The ability of these compounds to form stable inner salts was demonstrated. We have shown the glutathione peroxidase (GPx) like properties of selenazolopyridinium salts by oxidizing sulfur-containing natural amino acids, as well as aromatic and heteroaromatic aldehydes. The molecular structures of most of the compounds were confirmed by X-ray diffraction studies.
Visible-light induced copper(i)-catalysed denitrogenative oxidative coupling of hydrazinylpyridines with terminal alkynes
Charpe, Vaibhav Pramod,Hande, Aniket A.,Sagadevan, Arunachalam,Hwang, Kuo Chu
supporting information, p. 4859 - 4864 (2018/11/21)
Visible light mediated copper catalysed denitrogenative oxidative coupling of 2-hydrazinopyridines with terminal alkynes to form 2-(alkyl/arylethynyl) pyridines in the presence of O2 at room temperature is reported with 42 examples. This is the first report on visible light stimulated N2 elimination by an in situ generated copper(ii) superoxo/peroxo complex. N2 and water are the only by-products. The green chemistry metrics evaluation signifies that the current method is ecofriendly and economically feasible. This method allows the green synthesis of mGluR5 receptor antagonists, 2-methyl-6-(phenylethynyl)pyridine (MPEP) and 2-((3-methoxyphenyl)ethynyl)-6-methylpyridine (M-MPEP).
Unusual regioselectivity in the aldehyde addition reactions of allenyl/propargyl zirconium complexes derived from γ-(2-Pyridyl)propargyl ethers: Synthesis of multisubstituted α-hydroxyallenes
Fan, Guoqin,Xie, Xin,Liu, Yuanhong,Li, Yuxue
supporting information, p. 1636 - 1642 (2013/05/08)
Zirconium-mediated reactions of γ-(2-pyridyl)propargyl ethers with aldehydes afford α-hydroxyallenes selectively via the formation of allenyl/propargyl zirconium species. The reaction outcome is quite different to that of the reactions using propargylic ethers without a pyridyl group reported so far, in which homopropargyl alcohols were formed predominantly. The structure of allenylzirconium intermediate has been confirmed by X-ray crystal analysis which reveals an intramolecular Zr-N coordination. DFT calculations suggest that the smaller steric effect of the pyridine ring compared with the phenyl ring and its capability to form hydrogen bondings with hydrogen atoms of the Cp ligand and the aldehyde may account for the observed regioselectivity.
Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists
Chua, Peter C.,Nagasawa, Johnny Y.,Bleicher, Leo S.,Munoz, Benito,Schweiger, Edwin J.,Tehrani, Lida,Anderson, Jeffrey J.,Cramer, Merryl,Chung, Janice,Green, Mitchell D.,King, Chris D.,Reyes-Manalo, Grace,Cosford, Nicholas D.P.
, p. 4589 - 4593 (2007/10/03)
Structure-activity relationship studies leading to the discovery of novel mGlu5 receptor antagonists are described. These compounds show high in vitro potency, have good in vivo receptor occupancy, and a reasonable intravenous pharmacokinetic profile.
