29768-03-4

Basic information

• Product Name: 3-(2-PYRIDINYL)-2-PROPYN-1-OL
• Synonyms: 3-(2-PYRIDINYL)-2-PROPYN-1-OL;3-(Pyridin-2-yl)prop-2-yn-1-ol
• CAS NO: 29768-03-4
• Molecular Formula: C₈H₇NO
• Molecular Weight: 133.14728
• Mol File: 29768-03-4.mol
• Article Data: 31

Chemical Properties

• Melting Point: 85 °C
• Boiling Point: 125 °C(Press: 3 Torr)
• Appearance: /
• Density: 1.17±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.78±0.10(Predicted)
• CAS DataBase Reference: 3-(2-PYRIDINYL)-2-PROPYN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-PYRIDINYL)-2-PROPYN-1-OL(29768-03-4)
• EPA Substance Registry System: 3-(2-PYRIDINYL)-2-PROPYN-1-OL(29768-03-4)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41-43
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 29768-03-4(Hazardous Substances Data)

Upstream product

• 109-04-6 2-bromo-pyridine 
• 107-19-7 propargyl alcohol 
• 109-09-1 2-chloropyridine 
• 6175-54-8 hydroxy-1-propyne 
• 50-00-0 formaldehyd 
• 86521-05-3 2-(trimethylsilylethynyl)pyridine 
• 19070-80-5 n-<(trimethylsiloxy)methyl>phthalimide 
• 1945-84-2 2-ethynylpyridine 
• 694-59-7 pyridine N-oxide 
• 5029-67-4 2-iodopyridine 
• 51480-24-1 tetrahydropyranyloxypropargylmagnesium bromide 

Downstream Products

• 82244-21-1 2-phenyl-3-(2-pyridyl)-2-propen-1-ol 
• 76943-44-7 2,4,6-Trimethyl-benzenesulfonate1-amino-2-(3-hydroxy-prop-1-ynyl)-pyridinium; 
• 767-61-3 1-methylindolizine 
• 113985-52-7 (E)-3-(pyridin-2-yl)prop-2-en-1-ol 
• 24448-89-3 2-(3-hydroxypropyl)piperidine 
• 1599470-55-9 2-(3-(3-(4-methoxyphenyl)prop-2-ynyloxy)prop-1-ynyl)pyridine 
• 1599470-49-1 2-(3-(3-phenylprop-2-ynyloxy)prop-1-ynyl)pyridine 
• 113985-43-6 2-(3-methoxyprop-1-yn-1-yl)pyridine 
• 1338920-67-4 C₁₇H₁₁NO₂ 
• 1254485-96-5 ethyl 5-formyl-2-phenyl-4-(pyridin-2-yl)furan-3-carboxylate 
• 133739-01-2 4-methoxy-4-[3-(3-(pyridin-2-yl)prop-2-yn-1-yloxy)phenyl]tetrahydropyran 
• 82244-29-9 2-Phenyl-3-piperidin-1-yl-indolizine 
• 82244-38-0 2-phenyl-3-(2-pyridyl)-2-propenal 
• 2859-68-9 3-(pyridin-2-yl)-propanol 

Relevant articles and documents

Carreira alkynylations with paraformaldehyde. A mild and convenient protocol for the hydroxymethylation of complex base-sensitive terminal acetylenes via alkynylzinc triflates

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BICYCLIC JAK INHIBITORS AND USES THEREOF

Provided herein are compounds of Formulas (I), (II), (III), and (IV) and subformulas thereof, wherein the variables are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I), (II), (III), or (IV) and methods of using the compounds, e.g., in the treatment of immune disorders, inflammatory disorders, and cancer.

Sodium Phenoxide Mediated Hydroxymethylation of Alkynylsilanes with N-[(Trimethylsiloxy)methyl]phthalimide

The hydroxymethylation of alkynylsilanes with formaldehyde generated in situ from N-[(trimethylsiloxy)methyl]phthalimide proceeds in the presence of a stoichiometric amount of NaOPh. The reaction occurs at room temperature by using an operationally simple one-step procedure. A variety of alkynylsilanes possessing electron-donating, electron-withdrawing, and halogen groups (including heteroaryl-substituted alkynylsilanes) provide hydroxymethylated products.