297741-41-4

Upstream product

• 1053617-67-6 tert-Butyl-{(2S,3R,6S,8R,9S)-3-butyl-8-[2-(4-methoxy-benzyloxy)-ethyl]-9-methyl-3-methylsulfanylmethoxy-1,7-dioxa-spiro[5.5]undec-2-ylmethoxy}-diphenyl-silane 
• 250379-08-9 Triethyl-{(1R,2S)-1-[2-(4-methoxy-benzyloxy)-ethyl]-2-methyl-but-3-ynyloxy}-silane 
• 849619-01-8 1-(4-methoxybenzyloxy)-4-methylhex-5-en-3-ol 
• 250378-97-3 (S)-1-((R)-2-Butyl-tetrahydro-furan-2-yl)-ethane-1,2-diol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 128461-65-4 3-(p-methoxybenzyloxy)propanal 
• 1054709-81-7 (R)-4-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-4-methylsulfanylmethoxy-octanoic acid methoxy-methyl-amide 
• 3882-09-5 4-(allyloxy)-4-oxobutanoic acid 
• 297741-40-3 (2S,3R,6S,8R,9S)-3-Butyl-2-(tert-butyl-diphenyl-silanyloxymethyl)-8-[2-(4-methoxy-benzyloxy)-ethyl]-9-methyl-1,7-dioxa-spiro[5.5]undecan-3-ol 

Relevant academic research and scientific papers

Succinylation of Tertiary Alcohols under High Pressure

The efficient succinylation of the sterically hindered tertiary alcohols 1 was performed by reaction with succinic acid monomethyl and monoallyl ester (4a and 4b), respectively, in CH2Cl2 in the presence of dicyclohexylcarbodiimide and 4-(dimethylamino)pyridine under high pressure to give the methyl and allyl succinates 5a and 5b, respectively, in high yields. The succinates 5a,b were efficiently converted into the hemisuccinate 3a by treatment with lithium propyl mercaptide or by palladium(0)-catalyzed deallylation.

Total synthesis of reveromycin A

matrix presented The stereoselective total synthesis of reveromycin A (1), a potent inhibitor of eukaryotic cell growth, has been accomplished on the basis of the stereocontrolled construction of the 6,6-spiroketal system, efficient succinylation of the t