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2-[bis(2-chloroethyl)amino]-6-methoxy-2-oxidohexahydrofuro[3,4-d][1,3,2]oxazaphosphol-4-ylmethanol, commonly known as busulfan, is a potent chemotherapeutic agent utilized in the treatment of chronic myelogenous leukemia. It is classified as an alkylating agent and functions by inhibiting DNA synthesis and disrupting the replication of cancer cells. Busulfan is characterized by its ability to penetrate cancer cells and interfere with their growth, making it a valuable component in cancer treatment protocols.

29781-54-2

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29781-54-2 Usage

Uses

Used in Oncology:
Busulfan is used as an anticancer agent, specifically in the treatment of chronic myelogenous leukemia. It is effective due to its alkylating properties, which allow it to inhibit DNA synthesis and prevent the duplication of cancer cells. This action contributes to the suppression of tumor growth and the management of the disease.
Used in Bone Marrow Suppression Management:
In addition to its direct anticancer effects, busulfan is also used in combination with other chemotherapy drugs to manage bone marrow suppression. This condition can result from aggressive cancer treatments and may lead to a decrease in the production of essential blood cells. Busulfan, when used in combination with other agents, can help mitigate the severity of bone marrow suppression and support the overall health of the patient.
Used in Pre-Transplant Conditioning:
Busulfan is utilized as a component of the pre-transplant conditioning regimen in hematopoietic stem cell transplantation (HSCT). This procedure involves the infusion of healthy bone marrow or hematopoietic stem cells into a patient to replace damaged or destroyed bone marrow. The use of busulfan in the conditioning process helps to eradicate cancer cells and create space for the new, healthy cells to engraft and function properly.
Used in Drug Resistance Management:
Busulfan is also used to address drug resistance in cancer treatment. Its alkylating properties enable it to overcome certain resistance mechanisms, making it a valuable asset in the fight against multi-drug resistant cancers.

Check Digit Verification of cas no

The CAS Registry Mumber 29781-54-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,7,8 and 1 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 29781-54:
(7*2)+(6*9)+(5*7)+(4*8)+(3*1)+(2*5)+(1*4)=152
152 % 10 = 2
So 29781-54-2 is a valid CAS Registry Number.

29781-54-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name [2-[bis(2-chloroethyl)amino]-6-methoxy-2-oxo-3a,4,6,6a-tetrahydro-3H-furo[3,4-d][1,3,2]oxazaphosphol-4-yl]methanol

1.2 Other means of identification

Product number -
Other names (2-(Bis(2-chloroethyl)amino)-6-methoxy-2-oxidohexahydrofuro[3,4-d][1,3,2]oxazaphosphol-4-yl)methanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:29781-54-2 SDS

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