29786-39-8

Usage

Nitrile derivative

cyclobutane

Explanation

A nitrile derivative is a compound that contains a nitrile functional group (C≡N). In this case, the parent compound is cyclobutane, a four-membered ring hydrocarbon.

Explanation

The "1-(o-tolyl)" in the name indicates that a methyl group is attached to the ortho position (adjacent to the functional group) of a tolyl (methylphenyl) group.

Explanation

The presence of a nitrile functional group in the compound, which is a carbon-nitrogen triple bond, contributes to its unique reactivity and properties.

Explanation

1-(o-tolyl)cyclobutane-1-carbonitrile is commonly used as an intermediate in the synthesis of various compounds, including those in the pharmaceutical, agrochemical, and organic synthesis industries.

Ortho substitution

o-tolyl

Nitrile functional group

C≡N

Applications

pharmaceuticals, agrochemicals, and organic synthesis

Upstream product

• 109-64-8 1,3-dibromo-propane 
• 22364-68-7 2-tolylmethylnitrile 

Downstream Products

• 29973-64-6 <(1-o-Tolylcyclobutyl)carbonyl>carbamsaeureethylester 
• 29786-19-4 <(1-o-Tolylcyclobutyl)carbonyl>carbamsaeuremethylester 
• 29770-36-3 <1-(o-Tolylcyclobutyl)-carbonyl>-harnstoff 
• 29786-60-5 1-(o-Tolylcyclobutyl)-carbonylisocyanat 
• 29786-49-0 1-(o-tolyl)cyclobutane-1-carboxamide 

Relevant academic research and scientific papers

Oxadiazole Amine Derivative Compounds as Histone Deacetylase 6 Inhibitor, and the Pharmaceutical Composition Comprising the same

The present invention relates to a novel compound having an activity of inhibiting histone deacetylase 6 (HDAC6), an optical isomer thereof or a pharmaceutically acceptable salt thereof, a use thereof for preparation of a drug for treatment, a pharmaceutical composition comprising the same, a treatment method using the composition, and a method for preparing the same. The novel compound, an optical isomer thereof or a pharmaceutically acceptable salt thereof according to the present invention has an activity of inhibiting histone deacetylase 6 (HDAC6), and is effective for preventing or treating HDAC6-related diseases, including infectious diseases; neoplasm; endocrine, nutritional and metabolic diseases; mental and behavior disorders; nerve disorders; eye and adnexa diseases; cardiovascular diseases; respiratory diseases; digestive organ diseases; skin and subcutaneous tissue diseases; musculoskeletal and connective tissue diseases; or congenital malformation, deformation and chromosomal abnormality.COPYRIGHT KIPO 2017

NOVEL TRPV3 MODULATORS

Disclosed herein are modulators of TRPV3 of formula (I) wherein G1, X1, X2, X3, X4, X5, G2, Z1, Ra, Rb, u, and p are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.

NOVEL TRPV3 MODULATORS

Disclosed herein are modulators of TRPV3 of formula (I), wherein G1, X1, X2, X3, X4, X5, G2, Z1, Ra, Rb, u, and p are as defined in the specifica