29786-43-4

Basic information

• Product Name: 1-(3-(TrifluoroMethyl)phenyl)cyclobutanecarbonitrile
• Synonyms: 1-(3-(TrifluoroMethyl)phenyl)cyclobutanecarbonitrile;1-[3-(trifluoromethyl)phenyl]cyclobutane-1-carbonitrile
• CAS NO: 29786-43-4
• Molecular Formula: C₁₂H₁₀F₃N
• Molecular Weight: 225.2097096
• Mol File: 29786-43-4.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(3-(TrifluoroMethyl)phenyl)cyclobutanecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-(TrifluoroMethyl)phenyl)cyclobutanecarbonitrile(29786-43-4)
• EPA Substance Registry System: 1-(3-(TrifluoroMethyl)phenyl)cyclobutanecarbonitrile(29786-43-4)

Safety Data

• Hazardous Substances Data: 29786-43-4(Hazardous Substances Data)

Usage

General Description

1-(3-(TrifluoroMethyl)phenyl)cyclobutanecarbonitrile is a chemical compound with the molecular formula C12H9F3N and a molar mass of 221.2 g/mol. It is a cyclobutanecarbonitrile derivative containing a trifluoromethylphenyl group. 1-(3-(TrifluoroMethyl)phenyl)cyclobutanecarbonitrile is commonly used in the pharmaceutical industry as a building block for the synthesis of various biologically active molecules. It is also used in organic synthesis and chemical research. 1-(3-(TrifluoroMethyl)phenyl)cyclobutanecarbonitrile may have potential applications in the development of new drugs and materials due to its unique structure and properties. However, it also poses potential hazards and should be handled with care and proper safety precautions.

Upstream product

• 109-64-8 1,3-dibromo-propane 
• 2338-76-3 3-trifluoromethylphenylacetonitrile 

Downstream Products

• 151157-58-3 1-(3-trifluoromethylphenyl)cyclobutane carboxylic acid 
• 1432492-72-2 tert-butyl 2-(hydroxy(1-(3-(trifluoromethyl)phenyl)cyclobutyl)methyl)-pyridin-3-ylcarbamate 
• 1432048-60-6 (3-aminopyridin-2-yl){1-[3-(trifluoromethyl)phenyl]cyclobutyl}methanol 
• 1432492-71-1 1-(3-(trifluoromethyl)phenyl)cyclobutanecarbaldehyde 
• 1032464-46-2 C₁₃H₁₂F₃N₃S 
• 29786-33-2 (<1-(α,α,α-Trifluoro-m-tolyl)cyclobutyl>carbonyl)carbamsaeureethylester 
• 29973-63-5 (<1-(α,α,α-Trifluoro-m-tolyl)cyclobutyl>carbonyl)carbamsaeuremethylester 
• 29770-39-6 (<1-(α,α,α-Trifluor-m-tolyl)-cyclobutyl>-carbonyl)-harnstoff 
• 29770-26-1 <1-(α,α,α-Trifluor-m-tolyl)-cyclobutyl>-carbonylisocyanat 
• 29786-53-6 1-(3-(trifluoromethyl)phenyl)cyclobutane-1-carboxamide 

Relevant articles and documents

Synthesis method of arylcyclobutane compound

The present invention discloses a method for synthesizing an arylcyclobutane compound to 1eq phenylacetonitrile and 1.1eq 1-bromo-3-chloropropane as raw material, N,N- dimethylacetamide as a solvent, plus 2.5eq sodium hydride, under the protection of iner

Identification of A Novel Small-Molecule Binding Site of the Fat Mass and Obesity Associated Protein (FTO)

N-(5-Chloro-2,4-dihydroxyphenyl)-1-phenylcyclobutanecarboxamide (N-CDPCB, 1a) is found to be an inhibitor of the fat mass and obesity associated protein (FTO). The crystal structure of human FTO with 1a reveals a novel binding site for the FTO inhibitor and defines the molecular basis for recognition by FTO of the inhibitor. The identification of the new binding site offers new opportunities for further development of selective and potent inhibitors of FTO, which is expected to provide information concerning novel therapeutic targets for treatment of obesity or obesity-associated diseases.

NOVEL TRPV3 MODULATORS

Disclosed herein are modulators of TRPV3 of formula (II): wherein G1, X1, X2, X3, X4, X5, G2, Ra, Rb, and u are as defined in the specification. Composition