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5-Alpha-Dihydrocorticosterone, also known as 5α-DHC, is a naturally occurring steroid hormone derived from the adrenal glands. It is a metabolite of cortisol and plays a significant role in the regulation of electrolyte balance and blood pressure. 5α-DHC is formed through the reduction of cortisol by the enzyme 5α-reductase, which converts cortisol into its more potent form. This hormone is essential for maintaining proper fluid and electrolyte levels in the body, as it helps regulate the reabsorption of sodium and water in the kidneys. Additionally, 5α-DHC has been implicated in various physiological processes, including immune function and stress response. However, excessive levels of 5α-DHC can lead to health issues such as hypertension and electrolyte imbalances.

298-25-9

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298-25-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 298-25-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,9 and 8 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 298-25:
(5*2)+(4*9)+(3*8)+(2*2)+(1*5)=79
79 % 10 = 9
So 298-25-9 is a valid CAS Registry Number.
InChI:InChI=1/C21H32O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h12,14-17,19,22,24H,3-11H2,1-2H3/t12-,14-,15-,16+,17-,19+,20-,21-/m0/s1

298-25-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name (5S,8S,9S,10S,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one

1.2 Other means of identification

Product number -
Other names 5|A-Pregnane-11|A,21-diol-3,20-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:298-25-9 SDS

298-25-9Relevant academic research and scientific papers

Biotransformation of corticosteroids by Penicillium decumbens ATCC 10436

Holland, Herbert L.

, p. 646 - 649 (2007/10/02)

The biotransformation of a series of corticosteroids by the fungus Penicillium decumbens ATCC 10436 has been investigated. Conversion to the corresponding 5α-dihydroxteroid was observed for all the Δ4-3-ketosteroids studied with the exception of deoxycorticosterone, which was converted to a Δ14-diene. Deoxycorticosterone acetate was, however, converted to a 5α- dihydro product concomitant with ester hydrolysis. Other substrates carrying a C-21 acetoxy group were also hydrolyzed to the alcohol. In two cases (resulting from deoxycorticosterone acetate and 11-deoxycortisone) the 5α- 3-keto-product was further reduced to the 3β-alcohol. No reduction of δ14-dienes was observed.

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