29805-12-7

Basic information

• Product Name: 1-(3-chlorophenyl)-2-propyn-1-ol
• Synonyms: 1-(3-chlorophenyl)-2-propyn-1-ol
• CAS NO: 29805-12-7
• Molecular Weight: 166.607
• Mol File: 29805-12-7.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 1-(3-chlorophenyl)-2-propyn-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-chlorophenyl)-2-propyn-1-ol(29805-12-7)
• EPA Substance Registry System: 1-(3-chlorophenyl)-2-propyn-1-ol(29805-12-7)

Safety Data

• Hazardous Substances Data: 29805-12-7(Hazardous Substances Data)

Usage

Physical state

Solid

Color

White to light yellow

Solubility

Insoluble in water, soluble in organic solvents

Uses

a. Synthesis of pharmaceuticals and agrochemicals
b. Intermediate in organic chemical reactions (formation of esters and ethers)

Potential medicinal properties

a. Antimicrobial activity
b. Antitumor activity

Current status

Applications and uses are still being explored and researched

Upstream product

• 587-04-2 m-Chlorobenzaldehyde 
• 1066-54-2 trimethylsilylacetylene 
• 65032-27-1 ethynylmagnesium chloride 
• 4301-14-8 acetylenemagnesium bromide 

Downstream Products

• 1297409-49-4 1-(3-chlorophenyl)-2-(5-(3-chlorophenyl)furan-2-yl)ethanone 
• 1297409-13-2 1,6-bis(3-chlorophenyl)hexa-2,4-diyne-1,6-diol 
• 170800-61-0 1-(3-chlorophenyl)buta-2,3-dien-1-ol 
• 1361251-85-5 (R)-1-(3-chlorophenyl)buta-2,3-dien-1-ol 
• 131516-12-6 (R)-2-(3-chlorophenyl)-2,5-dihydrofuran 
• 131516-12-6 (S)-2-(3-chlorophenyl)-2,5-dihydrofuran 
• 33899-25-1 1-(3-chlorophenyl)-2-propyn-1-one 
• 338415-67-1 (E)-2-(3-chlorostyryl)benzo[d]oxazole 
• 770-23-0 (E)-3-(3-chlorophenyl)propenal 
• 1582792-94-6 1-(3-chlorophenyl)prop-2-yn-1-yl morpholine-4-carboxylate 
• 1411840-96-4 C₁₉H₁₃ClO₂ 

Relevant articles and documents

Allenylidene Induced 1,2-Metalate Rearrangement of Indole-Boronates: Diastereoselective Access to Highly Substituted Indolines

A process to achieve 1,2-metalate rearrangements of indole boronate as a way to access substituted indolines in high diastereoselectivities is presented. The reaction involves the generation of a Cu–allenylidene, which is sufficiently electrophilic to induce the 1,2-metalate rearrangement. The scope of the reaction is evaluated as well as further transformations of the product.

Synthesis of (Z)-alkene-containing linear conjugated dienyl homoallylic alcohols by a palladium-catalyzed three-component reaction

A synthesis of (Z)-alkene-containing linear conjugated dienyl homoallylic alcohols by using a palladium-catalyzed three-component reaction has been developed. This method shows good functional-group compatibility and generality, with high diastereoselectivity. Additionally, in many cases, the present method controls the alkene stereochemistry of the newly formed C-C bond and overcomes the inherent preference for (E)-alkene formation, giving (Z, E)- and (Z, Z)-products.

Enantioselective Propargylation of Polyols and Desymmetrization of meso 1,2-Diols by Copper/Borinic Acid Dual Catalysis

A copper/borinic acid dual catalytic reaction enabled the enantioselective propargylation of aliphatic polyols. Readily available reagents and catalysts were used in this transformation, which displayed good to excellent chemo- and stereoselectivity for a broad array of substrates. The method was also applicable to the desymmetrization of meso 1,2-diols to furnish products with three stereogenic centers and a terminal alkyne group in one operation.