29805-19-4Relevant academic research and scientific papers
Direct synthesis of pyrroles via 1,3-dipolar cycloaddition of azomethine ylides with ynones
Wang, Zheng,Shi, Ying,Luo, Xiaoyan,Han, De-Man,Deng, Wei-Ping
supporting information, p. 1742 - 1745 (2013/06/27)
A direct and facile synthesis of multi-substituted pyrroles via AgOAc-catalyzed 1,3-dipolar cycloaddition of azomethine ylides with ynones is developed, providing the corresponding adducts in moderate to high yields (up to 89%).
Enantioselective copper-catalyzed propargylic amination
Detz, Remko J.,Delville, Marielle M. E.,Hiemstra, Henk,Van Maarseveen, Jan H.
, p. 3777 - 3780 (2008/12/23)
(Chemical Equation Presented) A proper copper catalyst with a chiral pyridine-2,6-bisoxazoline (pybox) ligand was used to convert a variety of propargylic acetates with aromatic side chains (R = Ar) into their amine counterparts in high yield and with good selectivity (up to 88% ee). The resulting chiral propargylic amines can be elaborated further into P,N ligands (see scheme; DIPEA = diisopropylethylamine).
