29810-11-5

Upstream product

• 103-82-2 phenylacetic acid 
• 31491-21-1 2-phenyl-1,1-bis(trimethylsilyloxy)ethene 
• 2614-14-4 Phenylmalonic acid disodium salt 

Relevant academic research and scientific papers

Deracemizing α-Branched Carboxylic Acids by Catalytic Asymmetric Protonation of Bis-Silyl Ketene Acetals with Water or Methanol

We report a highly enantioselective catalytic protonation of bis-silyl ketene acetals. Our method delivers α-branched carboxylic acids, including nonsteroidal anti-inflammatory arylpropionic acids such as Ibuprofen, in high enantiomeric purity and high yields. The process can be incorporated in an overall deracemization of α-branched carboxylic acids, involving a double deprotonation and silylation followed by the catalytic asymmetric protonation.

The first synthesis of both enantiomers of [α-2H]phenylacetic acid in high enantiomeric excess

Arylmalonate decarboxylase (EC. 4. 1. 1. 76) catalysed decarboxylation followed by enantioface-differentiating protonation of [α-2H]- and [α-1H]phenylmalonic acid in 1H2O and 2H2O respectiv