29814-12-8

Basic information

• Product Name: 1-methylethyl (2Z)-2,3-dichloro-4-oxobut-2-enoate
• CAS NO: 29814-12-8
• Molecular Formula: C₇H₈Cl₂O₃
• Molecular Weight: 211.0426
• Mol File: 29814-12-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 269.1°C at 760 mmHg
• Flash Point: 112.7°C
• Density: 1.308g/cm³
• Vapor Pressure: 0.00738mmHg at 25°C
• Refractive Index: 1.48
• CAS DataBase Reference: 1-methylethyl (2Z)-2,3-dichloro-4-oxobut-2-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methylethyl (2Z)-2,3-dichloro-4-oxobut-2-enoate(29814-12-8)
• EPA Substance Registry System: 1-methylethyl (2Z)-2,3-dichloro-4-oxobut-2-enoate(29814-12-8)

Safety Data

• Hazardous Substances Data: 29814-12-8(Hazardous Substances Data)

Usage

Derived from esterification

2,3-dichloro-4-oxobut-2-enoic acid and isopropanol The compound is formed by the reaction between these two starting materials.

Uses

Intermediate in the synthesis of pharmaceuticals and agrochemicals It serves as a building block for creating various drugs and chemicals used in agriculture.

Unique structure and properties

The chemical's structure and properties make it versatile and valuable for organic synthesis in the pharmaceutical and agricultural industries.

Safety precautions

Hazardous if ingested, inhaled, or absorbed through the skin Proper handling and safety measures should be taken to avoid exposure and potential harm.

Upstream product

• 766-40-5 Mucochloric acid 
• 67-63-0 isopropyl alcohol 
• 87-56-9 mucochloric acid 

Relevant articles and documents

Analgesic Effects of 5-Alkyloxy-4-amino-2(5H)-furanones as Cholecystokinin-2 Antagonists

4-Amino-2(5H)-furanones were synthesized in high yields over two synthetic steps from readily available mucochloric acid. These 5-alkyloxy-4-amino-2(5H)-furanones were screened in a [125]I-CCK-8 radioligand receptor binding assay for CCK2 affinity and novel active ligands in the nanomolar range were identified. SAR was optimized leading to the cyclohexyl derivative 25 with an IC50 of 27 nM. Furanone 18 was obtained as a stable crystalline material with an IC50 of 85 nM, but had a higher CCK2 selectivity. It was subsequently tested in the isolated Guinea pig ileum assay with sulfated CCK8, and the CCK antagonizing properties of the ligand were confirmed. The CCK2 selective antagonist 18 was found to potentiate analgesia in the tail flick assay in mice, for the strong opiate morphine, the partial opiate agonist tramadol and the tricyclic antidepressant desimipramine. 4-Amino-2(5H)-furanones were synthesized and screened in a [125]I-CCK-8 radioligand receptor binding assay for CCK2 affinity. SAR optimization led to furanone 18 (IC50 = 85 nM). It was confirmed as antagonist in the isolated Guinea pig ileum assay and it was found to potentiate analgesia in the tail flick assay in mice, with morphine, tramadol, and desimipramine at 0.5 mg/kg.

NOVEL 4-AMINO-2(5H)-FURANONES

The present invention relates to compounds of formula (I): wherein X is selected from hydrogen, a halogen, a substituted or unsubstituted cyclic and heterocyclic moiety, substituted or unsubstituted, linear or branched alkyl, alkyloxy, alkylcarbonyl, alky

7-Chloro-7-cyanobicyclooctan-8-one (Prepared from Chlorocyanoketene)

The synthesis of 7-chloro-7-cyanobicyclooctan-8-one is described.This compound was prepared in 73percent yield from the cycloaddition of chlorocyanoketene to cyclohexene.The ketene, in turn, was generated from the thermolysis of 4-azido-3-chloro-5-isopropoxy-2(5H)-furanone.