298230-83-8

Basic information

• Product Name: 2-(3-BROMO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID
• Synonyms: AKOS AUF1148;2-(3-BROMO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID;4-Quinolinecarboxylic acid, 2-(3-broMophenyl)-;2-(3-bromophenyl)cinchoninic acid
• CAS NO: 298230-83-8
• Molecular Formula: C16H10BrNO2
• Molecular Weight: 328.16
• Mol File: 298230-83-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 487.8°Cat760mmHg
• Flash Point: 248.8°C
• Appearance: /
• Density: 1.556g/cm³
• Vapor Pressure: 2.49E-10mmHg at 25°C
• Refractive Index: 1.699
• CAS DataBase Reference: 2-(3-BROMO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-BROMO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID(298230-83-8)
• EPA Substance Registry System: 2-(3-BROMO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID(298230-83-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 298230-83-8(Hazardous Substances Data)

Usage

General Description

2-(3-Bromo-phenyl)-quinoline-4-carboxylic acid is a chemical compound that consists of a quinoline core with a carboxylic acid group and a 3-bromo-phenyl substituent. It has potential uses in research and pharmaceutical industries, where it can be utilized as a building block for the synthesis of various organic compounds, including pharmaceutical drugs and other bioactive molecules. 2-(3-BROMO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID is known for its ability to interact with biological systems and has shown potential in the development of novel drugs and therapies. Its unique structure and properties make it a valuable and versatile chemical for various applications in the field of chemistry and medicine.

InChI:InChI=1/C16H10BrNO2/c17-11-5-3-4-10(8-11)15-9-13(16(19)20)12-6-1-2-7-14(12)18-15/h1-9H,(H,19,20)

Upstream product

• 91-56-5 indole-2,3-dione 
• 2142-63-4 1-(3-Bromophenyl)ethanone 

Downstream Products

• 883526-03-2 2-(3-bromo-phenyl)-quinoline-4-carbonyl chloride 

Relevant articles and documents

Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases

A novel series of 32 sulfonamide containing quinolines (5a-j, 7a-k and 9a-k) were synthesized using tail approach and assayed for their carbonic anhydrase inhibitory potency against four human (h) carbonic anhydrase (CA) isoforms hCA I, II, IX and XII. Most of these newly synthesized compounds exhibited interesting inhibition potency against hCA I, II, IX and XII, in the nanomolar range with some derivatives being more potent than the standard drug acetazolamide (AAZ). The most effective ones on hCA I were 9b (91.8 nM), on hCA II: 5b (7.1 nM), 9c (9.6 nM) and on hCA IX: 5b (6.5 nM), 5g (21.4 nM), 5i (9.1 nM), 9a (22.8 nM), 9b (9.7 nM). Compounds 5h (8.8 nM), 7a (9.6 nM), 9d (6.9 nM), 9e (6.7 nM) were found highly effective against hCA XII. These 4-functionalized benzenesulfonamides (5a-5j, 9a-9k) were found to be more potent than the corresponding 3-functionalized derivatives (7a-k). These compounds may emerge as potential leads for the development of isoform selective hCA IX and XII inhibitors.