29824-06-4Relevant academic research and scientific papers
Discovery of new small molecules that influence neuroblast cell migration from the subventricular zone
Rolland, Amandine,Boquet, Isabelle,Norreel, Jean-Chretien,Moret, Vincent,Laras, Younes,Kraus, Jean-Louis
, p. 169 - 174 (2008/04/03)
Using SVZ (subventricular zone) tissue explants from one-day-old mice, we investigated the activity of new amino aromatic disulfide analogues and polyazamacrocycles on the migration of SVZ cells (neuroblasts). We found that among the tested analogues, non
Structure-Activity Relationships among Di- and Tetramine Disulfides Related to Benextramine
Alvarez, M.,Granados, R.,Mauleon, D.,Rosell, G.,Salas, M.,et al.
, p. 1186 - 1193 (2007/10/02)
The synthesis and irreversible α-blocking activity in the rat vas deferens of a series of tetra- and diamine disulfides 2-38, structural analogues of benextramine (BHC), are described. All compounds containing a central cystamine moiety displayed an irreversible α-adrenergic blockade at concentrations ranging from 10-4 to 6*10-6 M. Potency was increased in cystamines N,N'-disubstituted with 6-aminohexyl groups, especially when the outer nitrogen atoms bear arylalkyl substituents or are enclosed in a ring. However, N,N,N',N'-tetrasubstituted cystamines were poor blockers. Structural specificity in the outer portion of the tetramine disulfide is low, since many types of substituents gave rise to potent α-blockers. Even replacement of the outer amines with nonbasic ethers or amides was observed to maintain irreversible α-blockade.
