2986-50-7Relevant academic research and scientific papers
Odor-structure relationships using fluorine as a probe
Michel, Dominique,Schlosser, Manfred
, p. 4253 - 4260 (2007/10/03)
Eight ethers, nine esters and one ketone were submitted to a systematic structural variation by replacing a hydrogen atom in the vicinity of the oxofunction by fluorine and methyl. As long as steric factors dominate, a fluorine substituent alters the olfactory properties of the parent compound much less than a methyl substituent does. However, if it occupies a position adjacent to a carbonyl group, the halogen may more profoundly affect the odor perception, presumably as a consequence of conformational changes. (C) 2000 Elsevier Science Ltd.
