29865-52-9

Usage

Uses

Used in Organic Synthesis:
(4-Fluorophenyl)-2-nitropropane is used as an intermediate in organic synthesis for its ability to participate in a variety of chemical reactions, facilitating the creation of more complex organic molecules.
Used in Pharmaceutical Development:
In the pharmaceutical industry, (4-Fluorophenyl)-2-nitropropane is used as a building block for the development of new drugs, leveraging its unique structural features to enhance medicinal properties.
Used in Explosive Manufacturing:
(4-Fluorophenyl)-2-nitropropane is utilized in the manufacturing of explosives due to the reactivity of the nitro group, which is a common feature in many explosive compounds.
Used as a Fuel or Fuel Additive:
(4-FLUOROPHENYL)-2-NITROPROPANE has been studied for its potential use as a fuel or fuel additive, taking advantage of the energy content and combustion properties of nitroalkanes.
Each of these applications is based on the compound's chemical structure and the properties conferred by the nitro and fluorophenyl groups. Further research and experimentation would be necessary to fully explore and validate the practicality and safety of these uses.

Upstream product

• 134538-46-8 1-(4-fluorophenyl)-2-nitropropene 
• 459-57-4 4-fluorobenzaldehyde 

Relevant academic research and scientific papers

Iridium-catalyzed highly chemoselective and efficient reduction of nitroalkenes to nitroalkanes in water

An iridium-catalyzed highly chemoselective and efficient transfer hydrogenation reduction of structurally diverse nitroalkenes was realized at very low catalyst loading (S/C = up to 10000 or 20?000), using formic acid or sodium formate as a traceless hydride donor in water. Excellent functionality tolerance is also observed. The turnover number and turnover frequency of the catalyst reach as high as 18?600 and 19?200 h-1, respectively. An inert atmosphere protection is not required. The reactivities of nitroalkenes are dependent on their substitution pattern, and the pH value is a key factor to accomplish the complete conversion and excellent chemoselectivity. Purification of products is achieved by simple extraction without column chromatography. The reduction procedure is facilely amplified to 10 g scale at 10?000 S/C ratio. The potential of this green reduction in enantioselective hydrogenation has been demonstrated.

Enantioselective hydrogenation of α,β-disubstituted nitroalkenes

The first highly chemo- and enantioselective hydrogenation of α,β-disubstituted nitroalkenes was accomplished with rhodium/JosiPhos-J2 as a catalyst, with the yield and enantioselectivity of up to 95% and 94%, respectively. The α-chiral nitroalkanes will provide an entry to valuable chiral amphetamines which are otherwise not so easily accessed. This journal is the Partner Organisations 2014.

The highly chemoselective transfer hydrogenation of the carbon-carbon double bond of conjugated nitroalkenes by a rhodium complex

Chemoselective transfer hydrogenation of conjugated nitroalkenes catalyzed by [RhCl2Cp·]2-diamine complex (Cp ·=η5-C5Me5) using HCOOH/Et3N (5:2) (TEAF) as a hydrogen source was realized. A variety of nitrostyrenes, β-methyl nitrostyrenes, and 3-methyl-4-nitro-5-alkenyl- isoxazoles were reduced smoothly in good to excellent yields in short reaction time. Other functional groups are inert under the reaction conditions.