29866-18-0

Usage

Uses

Used in Plant Tissue Culture and Horticulture:
6-Benzyl-1H-purine is used as a growth promoter for inducing shoot development and improving the quality of plant regeneration from tissue culture. It significantly affects the growth and development of various plant species, making it a valuable tool in plant biotechnology and agricultural practices.
Used in Food Preservation:
6-Benzyl-1H-purine is studied for its potential applications in food preservation, although the specific reasons and mechanisms are not detailed in the provided materials.
Used in Medicine:
6-Benzyl-1H-purine is also being studied for its potential therapeutic applications in medicine, although the specific areas of medicine and reasons for its use are not provided in the materials.

InChI:InChI=1/C12H10N4/c1-2-4-9(5-3-1)6-10-11-12(15-7-13-10)16-8-14-11/h1-5,7-8H,6H2,(H,13,14,15,16)

Upstream product

• 28493-54-1 benzyltributyltin 
• 87-42-3 6-chloropurine 
• 7306-68-5 6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine 
• 62673-31-8 benzyl(bromo)zinc 
• 862098-07-5 6-benzyl-9-(tetrahydro-pyran-2-yl)-9H-purine 

Relevant academic research and scientific papers

6-Substituted purines as inhibitors of 15-lipoxygenase; a structure-activity study

15-Lipoxygenase (15-LO) has been implicated in oxidation of low-density lipoproteins (LDL), a process believed to be important for the development of atherosclerosis, as well as other pathogenic conditions. Potent and selective inhibitors of 15-LO may have a drug potential. In this study, purines with a variety of substituents have been examined as inhibitors of 15-lipoxygenase (15-LO) from soybeans. Several 6-substitued purines where the purine ring and a phenyl ring in the substituent were separated by a "spacer" were synthesized and their ability to inhibit the enzyme was explored. Separation of the purine and the phenyl rings with none, one or two sp3-carbons resulted in essentially inactive compounds, trans-styrylpurines and phenylethynylpurines, on the other hand, they exhibited activity close to the well-known 15-LO inhibitor quercetin. High activity was also found when the "spacer" was a trans-cyclopropyl ring. The shape of the spacer was important; a corresponding cis-cyclopropylpurine exhibited much less affinity for the enzyme. Only minor differences in inhibitory activity against 15-LO were found regardless of whether an N-substituent was situated on N-9 or N-7, even when the N-substituent was relatively large. Also, a variety of substituents in the purine 2- and 8-position were well tolerated.

Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors

On the basis of ATP adenine, a series of adenine and purine derivatives was prepared and tested for their ability to inhibit a spectrum of disease-related kinases. There has been scant research investigating the potential of cosubstrate derived kinase inhibitors for other kinases than CDKs. Our inhibitor design combined the purine system from the original cosubstrate ATP and phenyl moieties in order to explore possible interactions with the different regions of the ATP binding site in several disease-related protein kinases. There have been a number of hits for the assayed substances, which led us to conclude that the spectrum of compounds may prove to be a valuable tool kit for the evaluation of bonding and selectivity patterns for a wide variety of kinases.

6-Chloropurines and organostannanes in palladium catalyzed cross coupling reactions

Carbon-carbon bond formation in the purine 6-position can easily be accomplished by palladium catalyzed cross coupling between 6-chloropurines and organostannanes without protection of the purine ring NH function. This technique provides a convenient route to cytokinines.