29868-97-1 Usage
Description
Pirenzepine is an antagonist of M1 muscarinic acetylcholine receptors (Ki = 11.48 nM). It is selective for M1 over M2, M3, and M4 receptors (Kis = 602.56, 151.36, and 199.53 nM, respectively). Pirenzepine inhibits ascending reflex contraction of the circular smooth muscle in isolated guinea pig ileal segments induced by intraluminal balloon inflation (IC50 = 501.19 nM). It inhibits methacholine-induced increases in ileal pressure in guinea pigs (ID50 = 724.44 nmol/kg). Pirenzepine inhibits oxotremorine-induced gastric ulcer, gastric acid secretion, and salivation in rats (ED50s = 13, 37.5, and 620 μg/kg i.v., respectively). It prevents form-deprivation myopia (FDM) in a chick model of experimental myopia.
Chemical Properties
Solid
Uses
Different sources of media describe the Uses of 29868-97-1 differently. You can refer to the following data:
1. An antiulcerative. Tricyclic gastric-acid inhibitor.
2. Antiulcerative;M1 antagonist
General Description
Pirenzepine dihydrochloride is an anticholinergic agent. It is also considered as an antiulcer drug. It is used to treat myopia, gastric and duodenal ulcers. Pirenzepine dihydrochloride induces the dimerization of muscarinic M1 receptors.
Biochem/physiol Actions
Selective M1 muscarinic acetylcholine receptor antagonist.
Check Digit Verification of cas no
The CAS Registry Mumber 29868-97-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,8,6 and 8 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 29868-97:
(7*2)+(6*9)+(5*8)+(4*6)+(3*8)+(2*9)+(1*7)=181
181 % 10 = 1
So 29868-97-1 is a valid CAS Registry Number.
InChI:InChI=1/C19H21N5O2.ClH.H2O/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24;;/h2-8H,9-13H2,1H3,(H,21,26);1H;1H2
