298681-10-4Relevant articles and documents
COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES
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Paragraph 0681; 0714-0715, (2021/04/23)
The present invention provides a compound of formula (Ia) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, solid forms, combinations of pharmacologically active agents, pharmaceutical compositions and methods of using such compounds and solid forms thereof to treat or prevent parasitic diseases, for example malaria.
N-Bridged bicyclic sulfonamides as inhibitors of γ-secretase
Bowers, Simeon,Probst, Gary D.,Truong, Anh P.,Hom, Roy K.,Konradi, Andrei W.,Sham, Hing L.,Garofalo, Albert W.,Wong, Karina,Goldbach, Erich,Quinn, Kevin P.,Sauer, John-Michael,Wallace, William,Nguyen, Lan,Hemphill, Susanna S.,Bova, Michael P.,Basi, Guriqbal S.
scheme or table, p. 6952 - 6956 (2010/06/16)
The structural modification of a series of [3.3.1] bicyclic sulfonamide based γ-secretase inhibitors is described. Appropriate substitution on the bicyclic scaffold provides a significant increase in the metabolic stability of the compounds resulting in an improved in vivo metabolic profile.
QUINAZOLINE DERIVATIVES AS SRC TYROSINE KINASE INHIBITORS
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Page 77, (2008/06/13)
The invention concerns quinazoline derivatives of Formula (I): (A chemical formula should be inserted here - please see paper copy enclosed herewith) wherein Z is an O, S, SO, SO2, N(R2) or C(R2)2 group wherein each R2 group is hydrogen or (1-8C) alkyl, m is 0, 1, 2 or 3, each R1 group is selected from halogeno, (1-8C) alkyl, (1-6C) alkoxy and any of the other meanings defined in the description, n is 0, 1, 2 or 3, and each R3 group is selected from halogeno, (1-8C) alkyl, (1-6C) alkoxy and any of the other meanings defined in the description, or pharmaceutically-acceptable salts thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive agent in the containment and/or treatment of solid tumour disease.