298693-84-2Relevant academic research and scientific papers
A facile approach towards amidinophenylalanine derivatives as building blocks for the synthesis of non-natural peptides and peptidomimetics
Behrouz, Somayeh,Kühl, Nikos,Klein, Christian D.
, (2021)
The amidine function is extensively utilized as synthetic intermediate for structurally diverse heterocycles and as a core element in drugs and drug candidates. This study describes a facile and convenient approach for the highly efficient synthesis of amidinophenylalanine derivatives via the reduction of amidoximophenylalanines in the presence of Ac2O/AcOH/Zn at room temperature. The described process is attractive for process and medicinal chemistry due to its facility, safety, low cost, applicability for hydrogenation-sensitive compounds, and efficiency. Using this method, amidinophenylalanine derivatives as building blocks for peptides were obtained in excellent yields.
Process for synthesizing para-and/or meta-substituted cyanophenyalanine derivatives
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, (2008/06/13)
The present invention relates to a process for preparing a useful medicinal intermediate represented by the following formula (1): in which, R1, A and n are defined as described in the specification, or its stereoisomer, characterized in that a
Process for synthesizing para-and/or meta-substituted cyanophenylalanine derivatives
-
, (2008/06/13)
The present invention relates to a process for preparing a useful medicinal intermediate represented by the following formula (1): ???in which, R1, A and n are defined as described in the specification, or its stereoisomer, characterized in tha
