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4-METHYLBENZYLMAGNESIUM CHLORIDE is a chemical compound that serves as a reagent in organic synthesis, specifically as a source of the 4-methylbenzyl nucleophile in Grignard reactions. These reactions are crucial for the formation of carbon-carbon bonds in organic compounds, making 4-METHYLBENZYLMAGNESIUM CHLORIDE a valuable tool in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals. It is prepared in situ by reacting 4-methylbenzyl chloride with magnesium metal in anhydrous diethyl ether and must be used immediately due to its high reactivity and sensitivity to moisture and air.

29875-07-8

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29875-07-8 Usage

Uses

Used in Pharmaceutical Industry:
4-METHYLBENZYLMAGNESIUM CHLORIDE is used as a key reagent for the synthesis of various pharmaceuticals, contributing to the formation of complex molecular structures through Grignard reactions. Its ability to form carbon-carbon bonds is essential for creating the backbone of many medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical industry, 4-METHYLBENZYLMAGNESIUM CHLORIDE is utilized as a reagent in the synthesis of agrochemicals, such as pesticides and herbicides. Its role in forming carbon-carbon bonds is vital for constructing the active ingredients of these products, which are designed to protect crops and enhance agricultural yields.
Used in Fine Chemicals Industry:
4-METHYLBENZYLMAGNESIUM CHLORIDE is employed as a versatile reagent in the synthesis of fine chemicals, which are high-purity chemicals used in various applications, including fragrances, dyes, and specialty chemicals. Its contribution to the formation of carbon-carbon bonds is crucial for creating the intricate molecular structures required in these high-value products.
Used in Organic Synthesis Research:
4-METHYLBENZYLMAGNESIUM CHLORIDE is used as a research tool in organic synthesis, enabling chemists to explore new reaction pathways and develop innovative synthetic methods. Its reactivity and ability to form carbon-carbon bonds make it an indispensable component in the advancement of organic chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 29875-07-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,8,7 and 5 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 29875-07:
(7*2)+(6*9)+(5*8)+(4*7)+(3*5)+(2*0)+(1*7)=158
158 % 10 = 8
So 29875-07-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H9.ClH.Mg/c1-7-3-5-8(2)6-4-7;;/h3-6H,1H2,2H3;1H;/q-1;;+2/p-1

29875-07-8 Well-known Company Product Price

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  • Aldrich

  • (563773)  4-Methylbenzylmagnesiumchloridesolution  0.5 M in THF

  • 29875-07-8

  • 563773-50ML

  • 1,590.03CNY

  • Detail

29875-07-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name magnesium,1-methanidyl-4-methylbenzene,chloride

1.2 Other means of identification

Product number -
Other names 4-Methylbenzylmagnesium chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:29875-07-8 SDS

29875-07-8Upstream product

29875-07-8Relevant articles and documents

Syntheses of 7-Substituted Anthra[2,3- b]thiophene Derivatives and Naphtho[2,3- b:6,7- b']dithiophene

Al-Jumaili, Mustafa A.,Woodward, Simon

, p. 11437 - 11445 (2018/09/06)

7-R-Anthra[2,3-b]thiophene derivatives (1, R = H, Me, i-Pr, or MeO) are prepared in three steps (in average overall yield >50%) starting from (E)-4-RC6H4CH2(HOCH2)C=CI(CH2OH). The latter are commercial or readily prepared from 2-butyne-1,4-diol and ArCH2Cl (both costing 1 cent/mmol) at 10 g scales. These allow for the selective formation of (otherwise unattainable) higher solubility 7-derivatives. Similar methods allow for the preparation of naphtho[2,3-b:6,7-b']dithiophene 2 using equally low-cost starting materials.

HETEROCYCLIC COMPOUND DERIVATIVES AND MEDICINES

-

Page 29, (2010/02/05)

The present invention provides a compound which is useful as a PGI2 receptor agonist, and a pharmaceutical composition. The present invention is directed to a pharmaceutical composition comprising a compound represented by the following formula [1]: (R1 and R2 are the same or different and each represents optionally substituted aryl, Y represents N or CH, Z represents N or CH, A represents NH, NR5, O, S, or ethylene, R5 represents alkyl, D represents alkylene or alkenylene, E represents phenylene or single bond, G represents O, S, or CH2, R3 and R4 are the same or different and each represents hydrogen or alkyl, Q represents carboxy, alkoxycarbonyl, tetrazolyl, carbamoyl, or N-(alkylsulfonyl)carbamoyl), or a pharmaceutically acceptable salt thereof as an active ingredient.

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