29881-53-6

Basic information

• Product Name: 3-(acetylamino)-3-deoxy-1,2-O-(1-methylethylidene)pentofuranose
• CAS NO: 29881-53-6
• Molecular Formula: C₁₀H₁₇NO₅
• Molecular Weight: 231.2457
• Mol File: 29881-53-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 422.8°C at 760 mmHg
• Flash Point: 209.5°C
• Density: 1.28g/cm³
• Vapor Pressure: 6.43E-09mmHg at 25°C
• Refractive Index: 1.518
• CAS DataBase Reference: 3-(acetylamino)-3-deoxy-1,2-O-(1-methylethylidene)pentofuranose(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(acetylamino)-3-deoxy-1,2-O-(1-methylethylidene)pentofuranose(29881-53-6)
• EPA Substance Registry System: 3-(acetylamino)-3-deoxy-1,2-O-(1-methylethylidene)pentofuranose(29881-53-6)

Safety Data

• Hazardous Substances Data: 29881-53-6(Hazardous Substances Data)

Upstream product

• 14125-95-2 3-amino-3-deoxy-1,2-O-isopropylidene-α-D-ribofuranose 
• 108-24-7 acetic anhydride 

Relevant articles and documents

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Synthesis of tamiflu and its phosphonate congeners possessing potent anti-influenza activity

Using d-xylose as an appropriate chiral precursor, we have synthesized active neuraminidase inhibitor oseltamivir, antiflu drug Tamiflu, and novel phosphonate congeners that exhibit even stronger antiflu activities by inhibiting the neuraminidases of the wild-type and H274Y mutant of H1N1 and H5N1 viruses. Molecular modeling of the neuraminidase-phosphonate complex indicates a pertinent binding mode of the phosphonate with three arginine residues in the active site. Discovery of such potent neuraminidase inhibitors will offer an opportunity to the development of new anti-influenza drugs. Copyright