2989-10-8Relevant academic research and scientific papers
Tyrosinase and Layer-by-Layer supported tyrosinases in the synthesis of lipophilic catechols with antiinfluenza activity
Bozzini, Tiziana,Botta, Giorgia,Delfino, Michela,Onofri, Silvano,Saladino, Raffaele,Amatore, Donatella,Sgarbanti, Rossella,Nencioni, Lucia,Palamara, Anna Teresa
, p. 7699 - 7708 (2013)
Catechol derivatives with lipophilic properties have been selectively synthesized by tyrosinase in high yield avoiding long and tedious protection/deprotection steps usually required in traditional procedures. The synthesis was effective also with immobilized tyrosinase able to perform for more runs. The novel catechols were evaluated against influenza A virus, that continue to represent a severe threat worldwide. A significant antiviral activity was observed in derivatives characterized by antioxidant activity and long carbon alkyl side-chains, suggesting the possibility of a new inhibition mechanism based on both redox and lipophilic properties.
