299159-27-6

Basic information

• Product Name: 4-(4-IODOBENZYL)MORPHOLINE
• Synonyms: 4-(4-IODOBENZYL)MORPHOLINE;4-[(4-Iodophenyl)methyl]morpholine
• CAS NO: 299159-27-6
• Molecular Formula: C₁₁H₁₄INO
• Molecular Weight: 303.14
• Product Categories: Aromatic Morpholines
• Mol File: 299159-27-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 316.1°C at 760 mmHg
• Flash Point: 145°C
• Appearance: /
• Density: 1.604g/cm³
• Vapor Pressure: 0.000418mmHg at 25°C
• Refractive Index: 1.612
• PKA: 6.42±0.10(Predicted)
• CAS DataBase Reference: 4-(4-IODOBENZYL)MORPHOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-IODOBENZYL)MORPHOLINE(299159-27-6)
• EPA Substance Registry System: 4-(4-IODOBENZYL)MORPHOLINE(299159-27-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 299159-27-6(Hazardous Substances Data)

Usage

General Description

4-(4-Iodobenzyl)morpholine is a chemical compound that belongs to the class of morpholine derivatives. It is a halogenated organic compound with a molecular formula C11H14INO and a molecular weight of 307.14 g/mol. 4-(4-IODOBENZYL)MORPHOLINE is often used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It has a 4-iodobenzyl group attached to the morpholine ring and is commonly used as a building block in medicinal chemistry for the development of potential drug candidates. Additionally, 4-(4-Iodobenzyl)morpholine may also have applications in materials science and other industrial processes due to its unique chemical properties.

InChI:InChI=1/C11H14INO/c12-11-3-1-10(2-4-11)9-13-5-7-14-8-6-13/h1-4H,5-9H2

Upstream product

• 110-91-8 morpholine 
• 16004-15-2 1-bromomethyl-4-iodobenzene 
• 15164-44-0 p-(iodophenyl)carboxaldehyde 

Downstream Products

• 1093189-87-7 C₁₄H₁₇NO₂ 
• 1093190-80-7 4-(4-morpholin-4-ylmethylphenylsulfanyl)benzoic acid methyl ester 
• 1394862-49-7 1,3-bis(2-(4-(morpholinomethyl)phenyl)oxazol-5-yl)benzene 
• 1093190-84-1 N-((1S,2R)-2-hydroxy-1-hydroxycarbamoylpropyl)-4-(4-morpholin-4-ylmethylphenylsulfanyl)benzamide trifluoroacetate 
• 1093189-96-8 C₂HF₃O₂*C₂₂H₂₁NO₃ 
• 1093189-93-5 C₂HF₃O₂*C₂₂H₂₁NO₃ 
• 1093190-00-1 C₃₀H₃₆N₄O₆ 
• 1093189-99-1 C₃₁H₃₇N₃O₆ 
• 1093190-81-8 4-(4-morpholin-4-ylmethylphenylsulfanyl)benzoic acid hydrochloride 
• 1093190-82-9 (2S,3R)-3-hydroxy-2-(4-(4-morpholin-4-ylmethylbenzylsulfanyl)benzoylamino)butyric acid methyl ester 
• 1093189-90-2 C₂₂H₂₁NO₃ 
• 1093189-89-9 C₂₃H₂₃NO₃ 
• 1093189-88-8 C₁₄H₁₅NO₂ 

Relevant articles and documents

C(sp3)-H Monoarylation of Methanol Enabled by a Bidentate Auxiliary

With the assistance of a practical directing group (COAQ), the first catalytic protocol for the palladium-catalyzed C(sp3)-H monoarylation of methanol has been developed, offering an invaluable synthesis means to establish extensive derivatives of crucial arylmethanol functional fragments. Furthermore, the gram-scale reaction, broad substrate scope, excellent functional group compatibility, and even the practical synthesis of medicines further demonstrate the usefulness of this strategy.

ANTIBACTERIAL AGENTS

Antibacterial compounds of formula (I) are provided, as well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.

PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED ANILINE AND DIPHENYLAMINE ANALOGS

PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula (I): wherein R1, R2 R 3 and R4 are as defined herein.