299162-73-5 Usage
Uses
Used in Pharmaceutical Research:
1-(2-bromophenyl)-5-phenyl-1H-pyrazole is used as a key intermediate in the synthesis of pharmaceutical compounds for various therapeutic applications. Its unique structure allows for the development of new drugs with potential benefits in treating a range of medical conditions.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(2-bromophenyl)-5-phenyl-1H-pyrazole is employed as a structural component in the design and synthesis of novel molecules with potential pharmacological activities. Its incorporation into these molecules can lead to the discovery of new drugs with improved efficacy and selectivity.
Used in Drug Discovery:
1-(2-bromophenyl)-5-phenyl-1H-pyrazole plays a crucial role in drug discovery, as its structural features can be exploited to identify and optimize new lead compounds. 1-(2-bromophenyl)-5-phenyl-1H-pyrazole can be used to explore new chemical spaces and generate innovative drug candidates with potential applications in various therapeutic areas.
Used in Organic Synthesis:
As an organic chemical compound, 1-(2-bromophenyl)-5-phenyl-1H-pyrazole is also utilized in various organic synthesis processes. Its unique structure and reactivity make it a versatile building block for the creation of a wide array of organic molecules, including those with potential applications in materials science, agrochemicals, and other industries.
Check Digit Verification of cas no
The CAS Registry Mumber 299162-73-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,9,1,6 and 2 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 299162-73:
(8*2)+(7*9)+(6*9)+(5*1)+(4*6)+(3*2)+(2*7)+(1*3)=185
185 % 10 = 5
So 299162-73-5 is a valid CAS Registry Number.
299162-73-5Relevant academic research and scientific papers
Copper-mediated tandem ring-opening/cyclization reactions of cyclopropanols with aryldiazonium salts: Synthesis of: N -arylpyrazoles
Liu, Jidan,Xu, Erjie,Jiang, Jinyuan,Huang, Zeng,Zheng, Liyao,Liu, Zhao-Qing
, p. 2202 - 2205 (2020/02/26)
A general method for the synthesis of structurally diverse N-arylpyrazoles from readily available cyclopropanols and aryldiazonium salts is disclosed. The reaction was conducted at room temperature within minutes with a broad substrate scope and excellent regioselectivity.
A new germanium-based linker for solid phase synthesis of aromatics: Synthesis of a pyrazole library
Spivey, Alan C.,Diaper, Christopher M.,Adams, Harry,Rudge, Andrew J.
, p. 5253 - 5263 (2007/10/03)
An efficient synthesis of chlorogermane linker 12 is described. Economic introduction of germanium into this linker is accomplished by insertion of dichlorogermylene [from germanium(IV) chloride] into the homobenzylic C-Cl bond of 4-(2-chloroethyl)phenol 1. Using linker 12, transmetalation with lithiated 4-acetophenone, 3-acetophenone, and 4-(4'methoxy)biphenyl followed by Mitsunobu-type coupling to Argogel gives functionalized resins 14, 16, and 18, respectively. Treatment of resin 18 with TFA, ICl, Br2, or NCS effects clean ipso-degermylation releasing biphenyls 19-22, respectively. Resins 14 and 16 are employed for the parallel synthesis of a library of pyrazoles by enaminone formation (using Bredereck's reagent), condensative ring-closure (using a series of monosubstituted hydrazines), and cleavage (using TFA and Br2). Analysis of this library reveals the influence of the hydrazine substituent on both the regioselectivity of ring-closure and the propensity for electrophilic substitution at the 4-position of the pyrazoles during ipso-degermylative cleavage.
