299162-74-6

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-chlorophenyl)-5-phenyl-1H-pyrazole is used as a pharmaceutical agent for its potential anti-inflammatory, analgesic, and antipyretic properties. Its structural features allow it to interact with biological targets, making it a promising candidate for the development of new therapeutic agents to treat various conditions.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(2-chlorophenyl)-5-phenyl-1H-pyrazole is utilized as a potential pesticide. The presence of a chlorophenyl group may enhance its ability to target and control pests, thereby contributing to its effectiveness in this application.
Additionally, due to its structural versatility, 1-(2-chlorophenyl)-5-phenyl-1H-pyrazole serves as an important scaffold for the development of new chemical entities with therapeutic potential, further expanding its utility in the pharmaceutical sector.

Upstream product

• 41052-75-9 o-chlorophenylhydrazine hydrochloride 

Relevant academic research and scientific papers

A new germanium-based linker for solid phase synthesis of aromatics: Synthesis of a pyrazole library

An efficient synthesis of chlorogermane linker 12 is described. Economic introduction of germanium into this linker is accomplished by insertion of dichlorogermylene [from germanium(IV) chloride] into the homobenzylic C-Cl bond of 4-(2-chloroethyl)phenol 1. Using linker 12, transmetalation with lithiated 4-acetophenone, 3-acetophenone, and 4-(4'methoxy)biphenyl followed by Mitsunobu-type coupling to Argogel gives functionalized resins 14, 16, and 18, respectively. Treatment of resin 18 with TFA, ICl, Br2, or NCS effects clean ipso-degermylation releasing biphenyls 19-22, respectively. Resins 14 and 16 are employed for the parallel synthesis of a library of pyrazoles by enaminone formation (using Bredereck's reagent), condensative ring-closure (using a series of monosubstituted hydrazines), and cleavage (using TFA and Br2). Analysis of this library reveals the influence of the hydrazine substituent on both the regioselectivity of ring-closure and the propensity for electrophilic substitution at the 4-position of the pyrazoles during ipso-degermylative cleavage.