299171-56-5

Upstream product

• 1462-37-9 bromoethyl-2-benzyl ether 
• 105-45-3 acetoacetic acid methyl ester 
• 10385-30-5 4-(benzyloxy)butanoic acid 
• 38330-80-2 monomethyl monopotassium malonate 

Downstream Products

• 1197523-13-9 1-(4-Chlorophenyl)-5-(2,4-dichlorophenyl)-2-(3-hydroxypropyl)-1H-pyrrole-3-carboxylic acid 
• 1197522-71-6 4-(4-chlorophenyl)-1-{[1-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-2-(3-hydroxy propyl)-1H-pyrrol-3-yl]carbonyl}piperidine-4-carboxamide 
• 299171-41-8 (S)-3-[(R)-2,4-Bis-(tert-butyl-dimethyl-silanyloxy)-butyl]-5-methyl-3-phenylselanyl-dihydro-furan-2-one 
• 150055-68-8 (3S)-1,3-Bis(tert-butyldimethylsilyloxy)-6-benzyloxyhexane 
• 83458-93-9 (3S)-6-(Benzyloxy)hexane-1,3-diol 
• 187745-66-0 methyl (3S)-6-(benzyloxy)-3-hydroxyhexanoate 

Relevant academic research and scientific papers

SMALL MOLECULE MODULATORS OF IL-17

The present invention relates to a compound according to formula (I), (I) and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.

PYRROLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

The subject of the invention is compounds of formula (I): in which R1-R10 are as defined within, the method of preparation and therapeutic application as cannabinoid CB 1 receptor antagonists

A convergent total synthesis of (-)-mucocin: An acetogenin from Annonaceae

A total synthesis of the Annonaceous acetogenin mucocin has been accomplished. The synthesis follows a convergent strategy, wherein at a very late stage the left part of the molecule is connected with the right part. The key reaction is the stereocontrolled addition of an organomagnesium compound 2 to the aldehyde 3. The THP ring of mucocin is build by a 6-endo epoxide cyclization of an epoxyacetonide precursor (16 → 17). The new modular synthetic approach developed herein should be useful for the synthesis of other related natural products as well as pharmacologically interesting analogues.

Total synthesis of (-)-mucocin

A highly convergent, modular strategy for the total synthesis of the annonaceous acetogenin (-)-mucocin is reported. The remarkable features are the endoselective formation of the tetrahydropyran ring from an activated epoxide and the stability of the but