299173-15-2

Upstream product

• 165534-79-2 dimethyl 2-iodoterephthalate 
• 299173-24-3 [3-iodo-4-(methoxycarbonyl)]benzoic acid 

Downstream Products

• 1403326-68-0 methyl 2-chloro-4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)benzoate 
• 1403326-70-4 methyl 2-iodo-4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)benzoate 
• 1403326-72-6 2-chloro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoic acid 
• 1403326-74-8 2-iodo-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoic acid 
• 1403326-88-4 methyl 2-chloro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoate 
• 1403326-90-8 methyl 2-iodo-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoate 
• 1331832-72-4 C₂₄H₂₇ClO₂ 
• 299173-28-7 methyl 2-(3S,4R)-(3-benzyl-4-hydroxychroman-7-yl)-4-(1,1-difluoro-7-methanesulfonamidoheptyl)benzoate 
• 299173-14-1 methyl 2-(3S,4R)-(3-benzyl-4-hydroxychroman-7-yl)-4-(7-amino-1,1-difluoroheptyl)benzoate 
• 299173-22-1 methyl 2-(3S,4R)-(3-benzyl-4-hydroxychroman-7-yl)-4-(7-azido-1,1-difluoroheptyl)benzoate 
• 299173-27-6 methyl 2-iodo-4-(1-oxo-7-tosyloxyheptyl)benzoate 
• 299173-18-5 methyl 2-(3S,4R)-(3-benzyl-4-hydroxychroman-7-yl)-4-(1,1-difluoroethyl)benzoate 
• 299173-21-0 methyl 2-iodo-4-(7-azido-1,1-difluoroheptyl)benzoate 
• 299173-20-9 methyl 2-iodo-4-(7-azido-1-oxoheptyl)benzoate 

Relevant academic research and scientific papers

Modeling, Synthesis and Biological Evaluation of Potential RetinoidX Receptor-Selective Agonists: Novel Halogenated Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene)

The synthesis of halogenated analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (1), known commonly as bexarotene, and their evaluation for retinoidX receptor (RXR)-specific agonist performance is described. Compound 1 is FDA approved to treat cutaneous T-cell lymphoma (CTCL); however, bexarotene treatment can induce hypothyroidism and elevated triglyceride levels, presumably by disrupting RXR heterodimer pathways for other nuclear receptors. The novel halogenated analogues in this study were modeled and assessed for their ability to bind to RXR and stimulate RXR homodimerization in an RXRE-mediated transcriptional assay as well as an RXR mammalian-2-hybrid assay. In an array of eight novel compounds, four analogues were discovered to promote RXR-mediated transcription with EC50 values similar to that of 1 and are selective RXR agonists. Our approach also uncovered a periodic trend of increased binding and homodimerization of RXR when substituting a halogen atom for a proton ortho to the carboxylic acid on 1.

The synthesis of an aminohexyl-containing analog of the chromanol leukotriene B4 receptor antagonist CP-195543: A scaffold for the preparation of derivatized analogs

In order to allow the preparation of labeled derivatives of the leukotriene B4 (LTB4) antagonist CP-195543 for the study and/or 'visualization' of LTB4 receptors in in vitro and in vivo settings, we have synthesized an ami