299189-75-6

Upstream product

• 299189-69-8 3-[N-[2-(4-isopropylphenyl)ethyl]sulfamoyl]-4-methoxybenzamide 

Downstream Products

• 524743-47-3 5-cyano-N-[2-(4-isopropylphenyl)ethyl]-2-methoxy-N-methylbenzenesulfonamide 
• 524743-48-4 5-cyano-N-[2-(4-isopropylphenyl)ethyl]-2-methoxy-N-(1,3-thiazol-2-ylmethyl)benzenesulfonamide 
• 524743-46-2 ethyl [(5-cyano-2-methoxybenzenesulfonyl)-[2-(4-isopropylphenyl)ethyl]amino]acetate 

Relevant academic research and scientific papers

5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME, MEDICINAL USE THEREOF AND INTERMEDIATES IN THE PRODUCTION THEREOF

The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is an optionally substituted lower alkyl group, an optionally substituted lower alkoxy group, an optionally substituted lower alkenyl group, a cycloalkyl group or a lower acyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom or a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same and an intermediate thereof. These compounds are useful as preventives or remedies for various diseases such as brain infarction, cerebral thrombosis, cerebral embolism, TIA, cerebral vascular jerk, Alzheimer's diseases, myocardial infarction, heart attack, heart failure, thrombosis, pulmonary infarction and pulmonary embolism.

3-AMIDINOBENZENESULFONAMIDE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES IN THE PRODUCTION THEREOF

The present invention relates to 3-amidinobenzenesulfonamide derivatives represented by the general formula: wherein R1 represents a hydrogen atom or a hydroxy group; Y represents a single bond or an oxygen atom; and R2 represents a lower alkyl group or a group represented by the general formula: (wherein n represents 1 or 2; and T represents a hydrogen atom, a lower acyl group, a halo (lower acyl) group or a group represented by the general formula:-C(=NH)-W (wherein W represents a lower alkyl group)), and pharmaceutically acceptable salts thereof, which have an excellent activated blood coagulation factor X inhibitory activity and are useful as activated blood coagulation factor X inhibitors, and to pharmaceutical compositions comprising the same and intermediates thereof.