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Upstream product

• 141-97-9 ethyl acetoacetate 
• 6630-33-7 ortho-bromobenzaldehyde 
• 109-77-3 malononitrile 
• 7803-57-8 hydrazine hydrate 
• 2698-42-2 2-(2-bromobenzylidene)malononitrile 
• 132712-71-1 5-hydroxy-3-methylpyrazole 
• 108-26-9 3-methyl-2-pyrazoline-5-one 

Relevant academic research and scientific papers

Highly functionalized pyranopyrazoles: synthesis, antimicrobial activity, simulation studies and their structure activity relationships (SARs)

Abstract: Development of potent antibacterial and antifungal agents is a permanently new and unremitting investigation in the therapeutic field. Still, medicinal research wants to find the best antimicrobial agent. To attain this goal , here, the present work synthesis, simulation, and antimicrobial studies of pyranopyrazole derivatives were discussed. Among the reported compounds, 4b has dominant antimicrobial activity that was due to its higher dipole moment. Also, this compound has the most hydrophilic nature and low Eg value. Besides, compound 4e has the next higher dipole moment, hydrophilic property and efficient biological activity. The rationale of these results explained that the comparison of electronic results with biological data is the better way to find the potent pharmaceutical drug compounds. Graphical abstract: [Figure not available: see fulltext.]

Nano-Zn[2-boromophenylsalicylaldiminemethylpyranopyrazole]Cl2 as a novel nanostructured Schiff base complex and catalyst for the synthesis of pyrano[2,3-d]pyrimidinedione derivatives

Nano-Zn[2-boromophenylsalicylaldiminemethylpyranopyrazole]Cl2 (nano-[Zn-2BSMP]Cl2) as a novel nanostructured Schiff base complex was prepared and characterized using several techniques. Nano-[Zn-2BSMP]Cl2 was used as an ef

Novel biocompatible core/shell Fe3O4?NFC?Co(ii) as a new catalyst in a multicomponent reaction: An efficient and sustainable methodology and novel reusable material for one-pot synthesis of 4: H -pyran and pyranopyrazole in aqueous media

Today, due to the developing need for inexpensive catalysts, recyclable magnetic nanocatalysts immobilized on polysaccharides possess many advantages over classical heterogeneous catalysts. However, cellulose has been an appealing material in catalysis sc

Synthesis of 4-((2-hydroxynaphthalen-1-yl)(aryl)methyl)-5-methyl-2-phenyl-1H-pyrazol-3(2H)-ones using nano-Zn-[2-boromophenyl-salicylaldimine-methylpyranopyrazole]Cl2 nanoparticles

Nano-Zn-[2-boromophenyl-salicylaldimine-methylpyranopyrazole]Cl2 (nano-[Zn-2BSMP]Cl2) as a nanoparticle Schiff base complex and a catalyst was introduced for the solvent-free synthesis of 4-((2-hydroxynaphthalen-1-yl)(aryl)methyl)-5-

Synthesis of Pyranopyrazoles under Eco-friendly Approach by Using Acid Catalysis

Multicomponent synthesis of pyranopyrazole derivatives by using montmorillonite K-10 as a reusable green acid catalyst under eco-friendly method in the presence of eco-friendly solvent leads to novel protocol. Moreover, catalyst could be reused five times for the reaction without noticeable loss of activity. The scope of this path was to develop new synthetic molecules by using green catalysis for further screenings such as starting molecules for organic electronic materials and biological assays.

A green and clean pathway: One pot, multicomponent, and visible light assisted synthesis of pyrano[2,3-: C] pyrazoles under catalyst-free and solvent-free conditions

A mild, eco-efficient and metal-free synthetic protocol for the production of biologically significant scaffold dihydropyrano[2,3-c]pyrazoles via reaction between ethylacetoacetate (1), hydrazine hydrate (2), aromatic aldehydes (3) and malononitrile (4) a

Dihydropyrano [2,3-c] pyrazole: Novel in vitro inhibitors of yeast α-glucosidase

Inhibition of α-glucosidase enzyme activity is a reliable approach towards controlling post-prandial hyperglycemia associated risk factors. During the current study, a series of dihydropyrano[2,3-C] pyrazoles (1-35) were synthesized and evaluated for thei

Synthesis of 6-Amino-2,4-dihydropyrano[2,3-c ]pyrazol-5-carbonitriles Catalyzed by Silica-Supported Tetramethylguanidine under Solvent-Free Conditions

An efficient, high-yielding, and rapid protocol has been developed for the synthesis of diversity-oriented 6-amino-2,4-dihydropyrano[2,3-c]pyrazol-5- carbonitriles derivatives via a four-component, one-pot cyclocondensation reaction of ethyl acetoacetate, hydrazine hydrate, aldehydes, and malononitrile using silica-supported tetramethylguanidine as a heterogeneous catalyst for the first time. The protocol proves to be efficient and environmentally benign in terms of very easy workup, good yields, and ease of recovery of catalyst. In addition, the present method is superior in terms of green media, the amount of catalyst, and reaction time.

Synthesis of 6-amino-4-(4-methoxyphenyl)-5-cyano-3-methyl-1-phenyl-1,4- dihydropyrano[2,3-c]pyrazoles using disulfonic acid imidazolium chloroaluminate as a dual and heterogeneous catalyst

In this work, disulfonic acid imidazolium chloroaluminate {[Dsim]AlCl 4} is applied as a new acidic and heterogeneous catalyst for green, simple and efficient synthesis of 6-amino-4-(4-methoxyphenyl)-5-cyano-3-methyl- 1-phenyl-1,4-dihydropyrano

Synthesis of pyranopyrazoles using isonicotinic acid as a dual and biological organocatalyst

In this study, a green, simple and efficient method for the preparation of 6-amino-4-(4-methoxyphenyl)-5-cyano-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c] pyrazoles by means of a one-pot four component condensation reaction of aryl aldehydes, ethyl acetoacetate, malononitrile and hydrazine hydrate is reported. The reaction utilizes isonicotinic acid as a dual and biological organocatalyst at 85 °C under solvent-free conditions.