299215-40-0

Upstream product

• 5159-41-1 2-iodobenzyl alcohol 
• 26260-02-6 2-iodobenzaldehyde 
• 143-33-9 sodium cyanide 
• 506-59-2 N,N-dimethylammonium chloride 

Downstream Products

• 54616-46-5 2-Iodo-N,N-dimethylbenzamide 
• 299215-67-1 (E)-1,2-bis(2-iodophenyl)-N,N-dimethylethenylamine 
• 299215-77-3 (E)-N,N-dimethyl-2-(4,5-dimethoxy-2-iodophenyl)-1-(2-iodophenyl)ethenylamine 
• 299215-93-3 2-(4,5-dimethoxy-2-iodophenyl)-1-(2-iodophenyl)ethanone 
• 299215-95-5 2-(2-bromo-4,5-dimethoxy)-1-(2-iodophenyl)ethanone 
• 299215-85-3 1,2-bis(2-iodophenyl)ethanone 
• 299216-05-0 4-(4,5-dimethoxy-2-iodophenyl)-5-(2-iodophenyl)isoxazole 
• 299215-99-9 4,5-bis(2-iodophenyl)isoxazole 
• 478316-46-0 1-[5-(2-iodophenyl)-1H-pyrazol-4-yl]naphthalen-2-yl benzenesulfonate 
• 291536-99-7 2,4-dichloro-6-[2-(N,N-dimethylamino)-1-(2-iodobenzoyl)vinyl]phenyl benzenesulfonate 
• 478316-38-0 1-[2-(N,N-dimethylamino)-1-(2-iodobenzoyl)vinyl]naphthalen-2-yl benzenesulfonate 
• 291536-98-6 4-chloro-2-[2-(N,N-dimethylamino)-1-(2-iodobenzoyl)vinyl]phenyl benzenesulfonate 
• 478316-30-2 1-[2-(2-iodophenyl)-2-oxo-ethyl]naphthalen-2-yl benzenesulfonate 
• 478316-27-7 2,4-dichloro-6-[2-(2-iodophenyl)-2-oxo-ethyl]phenyl benzenesulfonate 

Relevant academic research and scientific papers

Revisiting the Ullmann-ether reaction: A concise and amenable synthesis of novel dibenzoxepino[4,5-d]pyrazoles by intramolecular etheration of 4,5-(o,o′-halohydroxy)arylpyrazoles

A concise synthesis of a series of novel dibenzoxepino[4,5-d]pyrazoles was accomplished by implementation of an intramolecular Ullmann-ether reaction on o,o'-halohydroxy-4,5-diarylpyrazoles mediated by CuBr·DMS. An alternative useful approach based on the palladium-catalyzed biarylether linkage formation (Buchwald-Hartwig reaction) was also successfully applied, offering limitations with regard to the steric demand of the substituents. The synthesis of the key o,o′-halohydroxy-4,5-diarylpyrazole intermediates proceeds through the construction of the heterocyclic ring by a tandem amine-exchange/heterocyclization sequence of 3-N,N-(dimethylamino)-1,2-diarylpropenones with phenylhydrazine followed by basic hydrolysis for deprotection. The enamino ketone precursors were conveniently prepared from the corresponding O-sulfonyloxy and O-benzoyloxy ortho-substituted 1,2-diarylethanones, starting from inexpensive salicylaldehyde or phenylacetic derivatives. Preliminary binding affinity experiments against peripheral and central nervous system receptors have been done with negative results.

A Convenient Strategy for the Synthesis of 4,5-Bis(o-haloaryl)isoxazoles

A series of new 1,2-bis(o-haloaryl)ethanones is efficiently prepared and applied to the synthesis of 4,5-bis(o-haloaryl)isoxazoles. Isolation of intermediate hydroxyisoxazolines, which are structurally examined, provides a definitive proof for a heterocyclization mechanism based on an amine exchange process. The isolation and X-ray crystallographic studies of significant side products such as benzamides and triarylpropionitriles are also described.