29922-49-4

Basic information

• Product Name: 2-hydroxymethyl-4-ethylphenol
• Synonyms: 2-hydroxymethyl-4-ethylphenol
• CAS NO: 29922-49-4
• Molecular Weight: 152.193
• Mol File: 29922-49-4.mol

Chemical Properties

• CAS DataBase Reference: 2-hydroxymethyl-4-ethylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxymethyl-4-ethylphenol(29922-49-4)
• EPA Substance Registry System: 2-hydroxymethyl-4-ethylphenol(29922-49-4)

Safety Data

• Hazardous Substances Data: 29922-49-4(Hazardous Substances Data)

Upstream product

• 97-94-9 triethyl borane 
• 2316-64-5 5-bromo-2-hydroxybenzyl alcohol 
• 50-00-0 formaldehyd 
• 123-07-9 4-Ethylphenol 
• 52411-35-5 5-ethyl-2-hydroxybenzaldehyde 

Relevant articles and documents

Water-promoted ortho-selective monohydroxymethylation of phenols in the NaBO2 system

Water-promoted ortho-selective monohydroxymethylation of phenols in the NaBO2 system generates salicyl alcohols in 65-97% yields. A remarkable rate-enhancement by water was observed, and NaBO2 appeared to serve the dual role of a suitable base and an efficient chelating reagent. This protocol possesses many advantages such as short reaction times, expanded substrate scope, and high mono- and regio-selectivities. The experimental results were explained by the calculations based on local ionisation energy minima, leading to a possible reaction mechanism.

B-Alkyl Suzuki-Miyaura cross-coupling of tri-n-alkylboranes with arylbromides bearing acidic functions under mild non-aqueous conditions

An efficient and chemoselective Pd-catalyzed B-alkyl Suzuki-Miyaura cross-coupling of tri-n-alkylboranes with arylbromides possessing acidic functions is described. This protocol features the relatively weak base Cs2CO3 and mild non-

Direct B-alkyl Suzuki-Miyaura cross-coupling of trialkyl-boranes with aryl bromides in the presence of unmasked acidic or basic functions and base-labile protections under mild non-aqueous conditions

An efficient and chemoselective palladium-catalyzed direct B-alkyl Suzuki-Miyaura cross-coupling of trialkylboranes with diversely functionalized aryl bromides is described. A wide variety of unmasked acidic or basic functions are tolerated. The mild non-

The synthesis of 2-hydroxymethyl derivatives of phenols

2-Hydroxymethylphenols have been prepared in good yield by reduction with sodium borohydride of the precursor aldehydes, obtained regiospecifically from reaction of phenols with paraformaldehyde in toluene containing stannic chloride and tri-n-butylamine. By contrast, reaction of phenols with either paraformaldehyde under anhydrous conditions or with aqueous formaldehyde results in formation of both the hydroxymethyl and the bishydroxymethyl derivatives. Cyclic acetals of the precursor aldehydes are readily accessible.