29936-64-9Relevant academic research and scientific papers
[Omim][BF4], a green and recyclable ionic liquid medium for the one-pot chemoselective synthesis of benzoxazinones
Sharifi, Ali,Barazandeh, Mehdi,Saeed Abaee,Mirzaei, Mojtaba
experimental part, p. 1852 - 1855 (2010/09/07)
An efficient procedure for the one-pot chemoselective synthesis of 2H-benzo[b][1,4]oxazin-3(4H)-one derivatives from their corresponding o-aminophenols is developed using DBU in the ionic liquid [omim][BF4]. Upon completion of the reaction and separation of the product, the ionic liquid is recovered and successfully reused over nine recycles without any noticeable loss of performance.
Synthesis and vasorelaxant activity of new 1,4-benzoxazine derivatives potassium channel openers
Caliendo, Giuseppe,Perissutti, Elisa,Santagada, Vincenzo,Fiorino, Ferdinando,Severino, Beatrice,Di Villa Bianca, Roberta d'Emmanuele,Lippolis, Laura,Pinto, Aldo,Sorrentino, Raffaella
, p. 2663 - 2669 (2007/10/03)
As part of a search for new potassium channel openers, the synthesis and vasorelaxant activity of new 1,4-benzoxazine derivatives derived from transformation of the benzopyran skeleton of cromakalim were described. Several new 1,4-benzoxazine derivatives were provided with significant vasorelaxant activity with an overall pharmacological behavior similar to CRK (1f, 1i, 2d, 2e, 2f and 2i).
Synthesis, biological activity and conformational study of 1,4- benzoxazine derivatives as potassium channel modulators
Caliendo, Giuseppe,Grieco, Paolo,Perissutti, Elisa,Santagada, Vincenzo,Santini, Antonello,Albrizio, Stefania,Fattorusso, Caterina,Pinto, Aldo,Sorrentino, Raffaella
, p. 957 - 967 (2007/10/03)
With the aim of discovering new molecules with K+-channel activating properties, we have synthesized derivatives of cromakalim (CRK), an important molecule which shows specific affinity towards K+ channels, by replacing the benzopyrane ring of this reference compound with a 1,4-benzoxazine moiety. A different number of substituents showing a good discrimination between hydrophobic and electronic properties have been inserted at the 6-position of the 1,4-benzoxazine ring. We describe here the synthesis and discuss the solid state conformation of these new molecules. When tested on rat aorta ring precontracted with phenylephrine, two compounds (2c and 2d) showed a concentration-dependent relaxation similar to that measured for cromakalim but less potent than this reference drug.
A New Reaction of Acid Chlorides. Intramolecular ortho-Chlorination
Byers, Maureen,Forrester, Alexander R.,John, I. Lennox,Thomson, Ronald H.
, p. 1092 - 1095 (2007/10/02)
2-(2-Arylazophenoxy)-2-methylpropanoic acids (1) react with thionyl chloride to form 4-(2-chloranilino)benzoxazinones (3) in high yield.The reaction proceeds through the acid chloride which undergoes cyclisation with intramolecular electrophilic transfer
