299396-92-2 Usage
Description
(R)-(+)-2-METHOXYPROPIONITRILE, also known as (R)-(+)-2-Methoxypropionitrile, is an organic compound with the chemical formula C4H7NO. It is a liquid at room temperature and is characterized by its unique chemical structure, which makes it a valuable building block in organic synthesis.
Uses
Used in Organic Synthesis:
(R)-(+)-2-METHOXYPROPIONITRILE is used as a synthetic building block for the creation of various organic compounds. Its unique structure allows it to be a versatile starting material for the synthesis of a wide range of molecules, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (R)-(+)-2-METHOXYPROPIONITRILE is used as an intermediate in the synthesis of chiral drugs. Its enantiomeric purity is crucial for the development of effective and safe medications, as the biological activity of chiral compounds can be significantly different between their enantiomers.
Used in Agrochemical Industry:
(R)-(+)-2-METHOXYPROPIONITRILE is also utilized in the agrochemical industry for the synthesis of chiral pesticides and other agrochemical products. Its use in this industry helps to create more targeted and environmentally friendly solutions for pest control and crop protection.
Used in Specialty Chemicals:
(R)-(+)-2-METHOXYPROPIONITRILE finds application in the synthesis of specialty chemicals, such as chiral ligands for asymmetric catalysis, chiral auxiliaries for organic reactions, and chiral building blocks for the development of new materials with unique properties.
Check Digit Verification of cas no
The CAS Registry Mumber 299396-92-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,9,3,9 and 6 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 299396-92:
(8*2)+(7*9)+(6*9)+(5*3)+(4*9)+(3*6)+(2*9)+(1*2)=222
222 % 10 = 2
So 299396-92-2 is a valid CAS Registry Number.
InChI:InChI=1/C4H7NO/c1-4(3-5)6-2/h4H,1-2H3/t4-/m1/s1
299396-92-2Relevant articles and documents
Sorbitol dehydrogenase inhibitors (SDIs): A new potent, enantiomeric SDI, 4-[2-1R-hydroxy-ethyl)-pyrimidin-4-yl]-piperazine-1-sulfonic acid dimethylamide
Mylari,Oates,Beebe,Brackett,Coutcher,Dina,Zembrowski
, p. 2695 - 2700 (2007/10/03)
We report here on our medicinal chemistry and pharmacology efforts to provide a potent sorbitol dehydrogenase inhibitor (SDI) as a tool to probe a recently disclosed hypothesis centered on the role of sorbitol dehydrogenase (SDH) in the second step of the polyol pathway, under conditions of high glucose flux. Starting from a weak literature lead, 2, and through newly developed structure-activity relationships, we have designed and executed an unambiguous synthesis of enantiomeric SDI, 6, which is at least 10 × more potent than 2. Also, 6 potently inhibits SDH in streptozotocin-diabetic rat sciatic nerve. We have described an expedient synthesis of a key building template, 33, for future research in the SDI area that may facilitate the discovery of even more potent SDIs with longer duration of action in vivo.
