29940-49-6

Upstream product

• 893842-26-7 5,5-dimethyl-2-(2,2,2-trifluoroacetyl)cyclohexane-1,3-dione 
• 61-82-5 3⁽⁵⁾-amino-1,2,4-triazole 
• 75039-59-7 2-dimethylaminomethylene-5,5-dimethylcyclohexane-1,3-dione 
• 126-81-8 dimedone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 696657-58-6 5,5-dimethyl-3-(1H-1,2,4-triazol-3-ylamino)-cyclohex-2-en-1-one 
• 78158-91-5 N¹,N¹-dimethyl-N²-(1,2,4-triazolyl-3-yl)formamidine 
• 61-82-5 3-amino-1,2,4-triazole 

Relevant academic research and scientific papers

Synthesis of 8,9-dihydro[1,2,4]triazolo[1,5-a]-quinazolin-6(7H)-one derivatives

Regioselectivity of the reactions of 1H-1,2,4-triazol-3-amines with 2-acyl-5,5-dimethylcyclohexane-1,3-diones and 2-dimethylaminomethylidene-5,5- dimethylcyclohexane-1,3-dione was studied. In all cases, the products were substituted 8,9-dihydro[1,2,4]triazolo[1,5-a]quinazolin-6(7H)-ones whose structure was determined by 1H and 13C NMR spectroscopy.

Synthesis of 8,8-R,R-8,9-dihydro[1,2,4]triazolo[1,5-a]quinazolin-6(7H)-ones

Three-component condensation of 3-amino-1,2,4-triazole (or its 5-methyl and 5-methylthio derivatives), dimedone (or cyclohexane-1,3-dione), and dimethylformamide dimethyl acetal afforded 8,8-R, R-8,9-dihydro[1,2,4] triazolo[1,5-a]quinazolin-6(7H)-ones.