299401-22-2Relevant academic research and scientific papers
Convenient synthesis and anti-proliferative activity of some benzochromenes and chromenotriazolopyrimidines under classical methods and phase transfer catalysis
Ali, Amira T.,Hekal, Mohamed H.
, p. 3498 - 3509 (2019/11/11)
A new series of benzochromene, benzochromenopyrimidine, and benzotriazolopyrimdine derivatives 3-10 were prepared via reaction of ethyl formimidate 2 with primary amines such as sulfanilamide, cyclohexylamine, 3-aminopyridine, 4-aminoantipyrine in addition to its reactions with different acid hydrazides. Compound 5 was further allowed to react with different C-electrophiles by classical and phase transfer catalysis conditions to get novel chromenotriazolopyrimidine derivatives. Screening of the antitumor activity in some of the newly synthesized compounds was tested in vitro against a panel of two human tumor cell lines namely HepG2 and HCT-116 cell lines. Compounds 4, 7, 8, 10, and 20 showed remarkable broad-spectrum antitumor activity.
Synthesis of novel fused coumarine and naphtho[2,1-b]pyrano[3,2-e][1,2,4] triazolo[1,5-c]pyrimidine derivatives
Said, Abderrahim Ben,Romdhane, Anis,Elie, Nicolas,Touboul, David,Jannet, Hichem Ben
, p. 185 - 190 (2013/07/26)
New 14-(Aryl)-14H-naphto[2,1-b]pyrano[3,2-e][1,2,4]triazolo[1,5-c] pyrimidine-2-Acetonitriles have been prepared. The chemical behaviour of these compounds was studied towards Knoevenagel condensation with salicylaldelyde derivatives, thus, a series of 2-
