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299407-82-2

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299407-82-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 299407-82-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,9,4,0 and 7 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 299407-82:
(8*2)+(7*9)+(6*9)+(5*4)+(4*0)+(3*7)+(2*8)+(1*2)=192
192 % 10 = 2
So 299407-82-2 is a valid CAS Registry Number.

299407-82-2Downstream Products

299407-82-2Relevant articles and documents

Identification of new nonsteroidal RORα ligands; Related structure-activity relationships and docking studies

Dubernet, Mathieu,Duguet, Nicolas,Colliandre, Lionel,Berini, Christophe,Helleboid, Stephane,Bourotte, Marilyne,Daillet, Matthieu,Maingot, Lucie,Daix, Sebastien,Delhomel, Jean-Francois,Morin-Allory, Luc,Routier, Sylvain,Walczak, Robert

supporting information, p. 504 - 508 (2013/07/26)

A high throughput screen was developed to identify novel, nonsteroidal RORα agonists. Among the validated hit compounds, the 4-(4-(benzyloxy) phenyl)-5-carbonyl-2-oxo-1,2,3,4-tetrahydropyrimidine scaffold was the most prominent. Among the numerous analogues tested, compounds 8 and 9 showed the highest activity. Key structure-activity relationships (SAR) were established, where benzyl and urea moieties were both identified as very important elements to maintain the activity. Most notably, the SAR were consistent with the binding mode of the compound 8 (S-isomer) in the RORα docking model that was developed in this program. As predicted by the model, the urea moiety is engaged in the formation of key hydrogen bonds with the backbone of Tyr380 and Asp382. The benzyl group is located in a wide hydrophobic pocket. The structural relationships reported in this letter will help in further optimization of this compound series and will provide novel synthetic probes helpful for elucidation of complex RORα physiopathology.

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