299418-13-6

Basic information

• Product Name: N'-[1-(4-chlorophenyl)ethylidene]isonicotinohydrazide
• Synonyms: N'-[1-(4-chlorophenyl)ethylidene]isonicotinohydrazide
• CAS NO: 299418-13-6
• Molecular Formula: C₁₄H₁₂ClN₃O
• Molecular Weight: 273.71758
• Mol File: 299418-13-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N'-[1-(4-chlorophenyl)ethylidene]isonicotinohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: N'-[1-(4-chlorophenyl)ethylidene]isonicotinohydrazide(299418-13-6)
• EPA Substance Registry System: N'-[1-(4-chlorophenyl)ethylidene]isonicotinohydrazide(299418-13-6)

Safety Data

• Hazardous Substances Data: 299418-13-6(Hazardous Substances Data)

Upstream product

• 54-85-3 isoniazid 
• 99-91-2 para-chloroacetophenone 
• 1570-45-2 isonicotinic acid ethylester 
• 55-22-1 pyridine-4-carboxylic acid 

Relevant articles and documents

Synthesis and antifungal activity in vitro of isoniazid Derivatives against histoplasma capsulatum var. Capsulatum

Histoplasmosis is a severe infection that affects millions of patients worldwide and is endemic in the Americas. Amphotericin B (AMB) and itraconazole are highly effective for the treatment of severe and milDer forms of the disease, but AMB is toxic, and the bioavailability of itraconazole is erratic. Therefore, it is important to investigate new classes of drugs for histoplasmosis treatment. In this study, a series of nine isoniazid hydrazone Derivatives were synthesized and evaluated for their antifungal activities in vitro against the dimorphic fungus Histoplasma capsulatum var. capsulatum. The drugs were tested by microdilution in accordance with CLSI guidelines. The compound N=-(1-phenylethylidene)isonicotinohydrazide had the lowest MIC range of all the compounds for the yeast and filamentous forms of H. capsulatum. The in vitro synergy of this compound with AMB against the planktonic and biofilm forms of H. capsulatum cells was assessed by the checkerboard method. The effects of this hydrazone on cellular ergosterol content and membrane integrity were also investigated. The study showed that the compound alone is able to reduce the ergosterol content of planktonic cells and can alter the membrane permeability of the fungus. Furthermore, the compound alone or in combination with AMB showed inhibitory effects against mature biofilms of H. capsulatum. N=-(1-Phenylethylidene)isonicotinohydrazide alone or combined with AMB might be of interest in the management of histoplasmosis. Copyright