299436-72-9Relevant academic research and scientific papers
Iron-Mediated Synthetic Routes to Unsymmetrically Substituted, Sterically Congested Benzophenones
Storm, J. Peter,Andersson, Carl-Magnus
, p. 5264 - 5274 (2007/10/03)
A new synthetic route to unsymmetrically substituted benzophenones, relying upon iron-mediated reactions in all of the key steps, is described. The key buiding block, η6-2-chloro-carbomethoxybenzene-η 5-cyclopentadienyl iron hexafluorophosphate (4), is reacted with a variety of substituted phenols, providing diaryl ether complexes (6). After hydrolysis of the ester functionalities, these complexes are subjected to Friedel-Crafts conditions. The efficiency of this intramolecular acylation reaction is very much dependent upon the substituents on the phenols. If these are appropriately chosen, xanthone complexes are isolated in fair to good yields. Regioselective ring-opening, using oxygen-nucleophiles, delivers substituted benzophenone complexes. After regioselective nucleophilic addition of cyanide ion, performed in the presence of DDQ, highly substituted benzophenones are isolated. To demonstrate the applicability of the new route, a formal synthesis of the benzophenone moiety of the protein kinase C inhibitor Balanol (3) is described.
An organoiron approach to the benzophenone appendage of the protein kinase C inhibitor balanol
Storm, J. Peter,Andersson, Carl-Magnus
, p. 1451 - 1453 (2008/02/09)
(formula presented) A new synthetic route to the benzophenone appendage of balanol, based on sequential iron-assisted nucleophilic aromatic substitution and ring-opening as well as regioselective oxidative cyanation, is described.
